The Amiloride-Sensitive Epithelial Na+ Channel PPK28 Is Essential for Drosophila Gustatory Water Reception
文献类型：期刊论文
| 作者 | Wang, Zuoren
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 30期号:18页码:6247-6252 |
| 关键词 | CANDIDATE TASTE RECEPTORS CAFFEINE RESPONSE NEURONS SYSTEM FAMILY MELANOGASTER GENES TRP |
| ISSN号 | 0270-6474 |
| 通讯作者 | Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China,ZuorenWang@ion.ac.cn |
| 英文摘要 | Water sensation is a specific taste modality in the fruit fly. Water-induced hypoosmolarity activates specific gustatory receptor neurons; however, the molecular identity of the putative osmolarity sensor in these neurons remains unknown. We found that amiloride and its analogs specifically antagonized the response of water gustatory receptor neurons and the behavior of flies toward water stimulation. Deletion of the gene that encodes the amiloride-sensitive PPK28 channel, a DEG/eNaC (degenerin/epithelial sodium channel) family member, abolished the water-induced activity of water gustatory receptor neurons and greatly diminished the behavioral response of flies to water. Ectopic expression of the PPK28 channel in the bitter cells within the intermediate-type sensilla renders these sensilla responsive to water stimuli. Thus, the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences Bai Ren; [973-2006CB806604]; [NSF30625020]; [KSCX1-YW-R-31] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1594]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经环路与动物行为研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Zuoren. The Amiloride-Sensitive Epithelial Na+ Channel PPK28 Is Essential for Drosophila Gustatory Water Reception[J]. JOURNAL OF NEUROSCIENCE,2010,30(18):6247-6252. |
| APA | Wang, Zuoren.(2010).The Amiloride-Sensitive Epithelial Na+ Channel PPK28 Is Essential for Drosophila Gustatory Water Reception.JOURNAL OF NEUROSCIENCE,30(18),6247-6252. |
| MLA | Wang, Zuoren."The Amiloride-Sensitive Epithelial Na+ Channel PPK28 Is Essential for Drosophila Gustatory Water Reception".JOURNAL OF NEUROSCIENCE 30.18(2010):6247-6252. |
入库方式： OAI收割
来源：上海神经科学研究所
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