Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
文献类型：期刊论文
| 作者 | Ji, Yuanyuan ; Lu, Yuan ; Yang, Feng ; Shen, Wanhua ; Tang, Tina Tze-Tsang ; Feng, Linyin ; Duan, Shumin ; Lu, Bai |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 13期号:3页码:302-U7 |
| 关键词 | NERVE GROWTH-FACTOR HIGH-FREQUENCY STIMULATION NEUROTROPHIC FACTOR BDNF LONG-TERM POTENTIATION SYNAPTIC-TRANSMISSION HIPPOCAMPAL-NEURONS DIFFERENTIAL REGULATION KINASE ACTIVATION ADULT HIPPOCAMPUS PC12 CELLS |
| ISSN号 | 1097-6256 |
| 通讯作者 | Lu, B (reprint author), GlaxoSmithKline Inc, R&D China, Shanghai, Peoples R China,bai.b.lu@gsk.com |
| 英文摘要 | Extracellular factors may act on cells in two distinct modes: an acute increase in concentration as a result of regulated secretion, or a gradual increase in concentration when secreted constitutively or from a distant source. We found that cellular responses to brain-derived neurotrophic factor ( BDNF) differed markedly depending on how BDNF was delivered. In cultured rat hippocampal neurons, acute and gradual increases in BDNF elicited transient and sustained activation of TrkB receptor and its downstream signaling, respectively, leading to differential expression of Homer1 and Arc. Transient TrkB activation promoted neurite elongation and spine head enlargement, whereas sustained TrkB activation facilitated neurite branch and spine neck elongation. In hippocampal slices, fast and slow increases in BDNF enhanced basal synaptic transmission and LTP, respectively. Thus, the kinetics of TrkB activation is critical for cell signaling and functions. This temporal dimension in cellular signaling may also have implications for the therapeutic drug design. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Institute on Child Health and Human Development; National Institute of Mental Health |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1603]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ji, Yuanyuan,Lu, Yuan,Yang, Feng,et al. Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons[J]. NATURE NEUROSCIENCE,2010,13(3):302-U7. |
| APA | Ji, Yuanyuan.,Lu, Yuan.,Yang, Feng.,Shen, Wanhua.,Tang, Tina Tze-Tsang.,...&Lu, Bai.(2010).Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons.NATURE NEUROSCIENCE,13(3),302-U7. |
| MLA | Ji, Yuanyuan,et al."Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons".NATURE NEUROSCIENCE 13.3(2010):302-U7. |
入库方式： OAI收割
来源：上海神经科学研究所
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