Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila
文献类型：期刊论文
| 作者 | Huang, Fu-De
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 30期号:4页码:1512-1522 |
| 关键词 | LONG-TERM POTENTIATION IMPAIR SYNAPTIC PLASTICITY INTRANEURONAL-A-BETA ALZHEIMERS-DISEASE TRANSGENIC MICE PRECURSOR PROTEIN MITOCHONDRIAL DYSFUNCTION COGNITIVE DECLINE PLAQUE-FORMATION NEURODEGENERATIVE DISEASES |
| ISSN号 | 0270-6474 |
| 通讯作者 | Huang, FD (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,fdhuang@ion.ac.cn |
| 英文摘要 | Alzheimer's disease (AD) is attributable to synapse dysfunction and loss, but the nature and progression of the presynaptic structural and functional changes in AD are essentially unknown. We expressed wild-type or arctic form of beta amyloid(1-42) (A beta) in a small group of neurons in the adult fly and performed extensive time course analysis of the function and structure of both axon and presynaptic terminals at the identified single-neuron level. A beta accumulated intracellularly and induced a range of age-dependent changes, including depletion of presynaptic mitochondria, slowdown of bi-directional transports of axonal mitochondria, decreased synaptic vesicles, increased large vacuoles, and elevated synaptic fatigue. These structural and functional synaptic changes correlated with age-dependent deficit in motor behavior. All these alterations were accelerated in flies expressing the arctic form of A beta. The depletion of presynaptic mitochondria was the earliest detected phenotype and was not caused by the change in axonal transport of mitochondria. Moreover, axonal mitochondria exhibited a dramatic reduction in number but a significant increase in size in aged A beta-expressing flies, indicating a global depletion of mitochondria in the neuron and an impairment of mitochondria fission. These results suggest that A beta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 Program[2006CB806600, 2007CB947101]; Knowledge Innovation Engineering Project of the Chinese Academy of Sciences[KSCX2-YW-R-099]; Shanghai Municipal Program for Basic Research[06dj14010] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1620]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经退行性疾病研究小组 |
| 推荐引用方式 GB/T 7714 | Huang, Fu-De. Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila[J]. JOURNAL OF NEUROSCIENCE,2010,30(4):1512-1522. |
| APA | Huang, Fu-De.(2010).Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila.JOURNAL OF NEUROSCIENCE,30(4),1512-1522. |
| MLA | Huang, Fu-De."Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila".JOURNAL OF NEUROSCIENCE 30.4(2010):1512-1522. |
入库方式： OAI收割
来源：上海神经科学研究所
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