Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila
文献类型：期刊论文
| 作者 | Li, Xinjian ; Yu, Feng ; Guo, Aike |
| 刊名 | SLEEP
 |
| 出版日期 | 2009 |
| 卷号 | 32期号:11页码:1417-1424 |
| 关键词 | Drosophila sleep learning and memory cAMP slpD mushroom body MUSHROOM BODY RAT HIPPOCAMPUS REDUCED SLEEP REM-SLEEP CONSOLIDATION MELANOGASTER MAINTENANCE NEURONS STRESS BODIES |
| ISSN号 | 0161-8105 |
| 通讯作者 | Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China,Hakguo@ion.ac.cn |
| 英文摘要 | Study Objectives: Sleep is crucial to memory consolidation in humans and other animals; however, the effect of insufficient sleep on subsequent learning and memory remains largely elusive. Design: Learning and memory after 1-day sleep deprivation (slpD) was evaluated using Pavlovian olfactory conditioning in Drosophila, and locomotor activity was measured using the Drosophila Activity Monitoring System in a 12:12 light-dark cycle. Results: We found that slpD specifically impaired 1-h memory in wild type Canton-S flies, and this effect could persist for at least 2 h. However, alternative stresses (heat stress, oxidative stress, starvation, and rotation stress) did not result in a similar effect and left the flies' memory intact. Mechanistic studies demonstrated that flies with either silenced transmission of the mushroom body (MB) during slpD or down-regulated cAMP levels in the MB demonstrated no slpD-induced 1-h memory impairment. Conclusion: We found that slpD specifically impaired 1-h memory in Drosophila, and either silencing of MB transmission during slpD or down-regulation of the cAMP level in the MB protected the flies from slpD-induced impairment. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China[30270341, 30630028, 30621004]; Multidisciplinary Research Program (Brain and Mind); Chinese Academy of Sciences, Major State Basic Research Program[G20000 77800, 2006CB806600, 2006CB911003, KJCX 1-09-03, KSCX2-YW-R-28] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1632]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Xinjian,Yu, Feng,Guo, Aike. Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila[J]. SLEEP,2009,32(11):1417-1424. |
| APA | Li, Xinjian,Yu, Feng,&Guo, Aike.(2009).Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila.SLEEP,32(11),1417-1424. |
| MLA | Li, Xinjian,et al."Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila".SLEEP 32.11(2009):1417-1424. |
入库方式： OAI收割
来源：上海神经科学研究所
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