SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice
文献类型：期刊论文
| 作者 | Zhang, Xiaochang ; Lei, Kai ; Yuan, Xiaobing ; Wu, Xiaohui ; Zhuang, Yuan ; Xu, Tian ; Xu, Rener ; Han, Min |
| 刊名 | NEURON
 |
| 出版日期 | 2009 |
| 卷号 | 64期号:2页码:173-187 |
| 关键词 | DREIFUSS MUSCULAR-DYSTROPHY CENTRAL-NERVOUS-SYSTEM MEMBRANE PROTEIN NEUROMUSCULAR-JUNCTION ACTIN CYTOSKELETON CELL POLARIZATION SKELETAL-MUSCLE ENVELOPE LIS1 DYNEIN |
| ISSN号 | 0896-6273 |
| 通讯作者 | Xu, R (reprint author), Fudan Univ, Sch Life Sci, Inst Dev Biol & Mol Med, Shanghai 200433, Peoples R China,rener_xu@fudan.edu.cn ; mhan@colorado.edu |
| 英文摘要 | Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus during interkinetic nuclear migration (INM) and nucleokinesis, the factors connecting dynein/Lis1 to the nuclear envelope (NE) remain to be determined. We report here that the SUN-domain proteins SUM and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and neuronal migration in mice. We show that SUM and SUN2 redundantly form complexes with Syne-2 to mediate the centrosome-nucleus coupling during both INM and radial neuronal migration in the cerebral cortex. Syne-2 is connected to the centrosome through interactions with both dynein/dynactin and kinesin complexes. Syne-2 mutants also display severe defects in learning and memory. These results fill. an important gap in our understanding of the mechanism of nuclear movement during brain development. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Talent Training Fund in Basic Research of China[J0630643]; Ministry of Science and Technology; National Natural Science Foundation of China; Ministry of Education of China; Shanghai Municipal Government |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1633]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaochang,Lei, Kai,Yuan, Xiaobing,et al. SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice[J]. NEURON,2009,64(2):173-187. |
| APA | Zhang, Xiaochang.,Lei, Kai.,Yuan, Xiaobing.,Wu, Xiaohui.,Zhuang, Yuan.,...&Han, Min.(2009).SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice.NEURON,64(2),173-187. |
| MLA | Zhang, Xiaochang,et al."SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice".NEURON 64.2(2009):173-187. |
入库方式： OAI收割
来源：上海神经科学研究所
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