Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
文献类型：期刊论文
| 作者 | Shu, Yousheng
|
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2009 |
| 卷号 | 12期号:8页码:996-U61 |
| 关键词 | NEOCORTICAL PYRAMIDAL NEURONS DEPENDENT SYNAPTIC PLASTICITY SODIUM-CHANNELS ION CHANNELS CELL-TYPE AXON SEGMENT ACTIVATION SPIKES MODEL |
| ISSN号 | 1097-6256 |
| 通讯作者 | Shu, YS (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai, Peoples R China,shu@ion.ac.cn |
| 英文摘要 | The distal end of the axon initial segment (AIS) is the preferred site for action potential initiation in cortical pyramidal neurons because of its high Na+ channel density. However, it is not clear why action potentials are not initiated at the proximal AIS, which has a similarly high Na+ channel density. We found that low-threshold Na(v)1.6 and high-threshold Na(v)1.2 channels preferentially accumulate at the distal and proximal AIS, respectively, and have distinct functions in action potential initiation and backpropagation. Patch-clamp recording from the axon cut end of pyramidal neurons in the rat prefrontal cortex revealed a high density of Na+ current and a progressive reduction in the half-activation voltage (up to 14 mV) with increasing distance from the soma at the AIS. Further modeling studies and simultaneous somatic and axonal recordings showed that distal Na(v)1.6 promotes action potential initiation, whereas proximal Na(v)1.2 promotes its backpropagation to the soma. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 Program[2006CB806600]; Shanghai Commission of Science and Technology[06DJ14010]; Shanghai Pujiang Program[07PJ14108]; Chinese Academy of Sciences[KSCX2-YW-R-102]; Scientific Research Foundation of the State Human Resource Ministry and the Education Ministry |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1652]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组 |
| 推荐引用方式 GB/T 7714 | Shu, Yousheng. Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation[J]. NATURE NEUROSCIENCE,2009,12(8):996-U61. |
| APA | Shu, Yousheng.(2009).Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.NATURE NEUROSCIENCE,12(8),996-U61. |
| MLA | Shu, Yousheng."Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation".NATURE NEUROSCIENCE 12.8(2009):996-U61. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。