Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration
文献类型：期刊论文
| 作者 | Tong, Xiao-ping ; Li, Xiang-yao ; Zhou, Bing ; Shen, Wanhua ; Zhang, Zhi-jun ; Xu, Tian-Le(徐天乐) ; Duan, Shumin |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 186期号:1页码:113-128 |
| ISSN号 | 0021-9525 |
| 关键词 | OLIGODENDROCYTE PRECURSOR CELLS GIANT DEPOLARIZING POTENTIALS POSTNATAL SUBVENTRICULAR ZONE CENTRAL-NERVOUS-SYSTEM CNS WHITE-MATTER RAT OPTIC-NERVE NEURONAL MIGRATION MULTIPLE-SCLEROSIS ADHESION MOLECULE PROGENITOR CELLS |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn |
| 英文摘要 | NG2 cells originate from various brain regions and migrate to their destinations during early development. These cells express voltage-gated Na+ channels but fail to produce typical action potentials. The physiological role of Na+ channels in these cells is unclear. We found that GABA induces membrane depolarization and Ca2+ elevation in NG2 cells, a process requiring activation of GABA(A) receptors, Na+ channels, and Na+/Ca2+ exchangers (NCXs), but not Ca2+ channels. We have identified a persistent Na+ current in these cells that may underlie the GABA-induced pathway of prolonged Na+ elevation, which in turn triggers Ca2+ influx via NCXs. This unique Ca2+ signaling pathway is further shown to be involved in the migration of NG2 cells. Thus, GABAergic signaling mediated by sequential activation of GABA(A) receptors, noninactivating Na+ channels, and NCXs may play an important role in the development and function of NG2 glial cells in the brain. |
| 学科主题 | Cell Biology |
| 资助信息 | Major State Basic Research Program of China[2006CB806600]; National Natural Science Foundation of China[30730037]; Chinese Academic Sciences[KSCX2-YWR101]; Science and Technology Commission of Shanghai Municipality[07XD14039] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1653]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Tong, Xiao-ping,Li, Xiang-yao,Zhou, Bing,et al. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration[J]. JOURNAL OF CELL BIOLOGY,2009,186(1):113-128. |
| APA | Tong, Xiao-ping.,Li, Xiang-yao.,Zhou, Bing.,Shen, Wanhua.,Zhang, Zhi-jun.,...&Duan, Shumin.(2009).Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration.JOURNAL OF CELL BIOLOGY,186(1),113-128. |
| MLA | Tong, Xiao-ping,et al."Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration".JOURNAL OF CELL BIOLOGY 186.1(2009):113-128. |
入库方式： OAI收割
来源：上海神经科学研究所
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