Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons
文献类型：期刊论文
| 作者 | Liao, Chun-yang ; Cui, Lin ; Zhou, Qun-fang ; Duan, Shu-min ; Jiang, Gui-bin |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 27期号:3页码:338-344 |
| ISSN号 | 1382-6689 |
| 关键词 | Perfluorooctane sulfonate (PFOS) Neurotoxicity Potassium channel Sodium channel Glutamate-activated current VENTRICULAR MYOCYTES PERFLUORINATED COMPOUNDS PERFLUOROALKYL ACIDS PFOA CONCENTRATIONS MASS-SPECTROMETRY NHANES 1999-2000 NATIONAL-HEALTH US POPULATION K+ CURRENT INHIBITION |
| 通讯作者 | Jiang, GB (reprint author), Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, POB 2871, Beijing 100085, Peoples R China,gbjiang@rcees.ac.cn |
| 英文摘要 | Concern on an emerging persistent contaminant, perfluorooctane sulfonate (PFOS), is increasingly growing. Although the fate, transport. distribution and bioaccumulation of PFOS have been documented, its toxicological effects especially neurotoxicity remain largely unknown. In this study, the effects of PFOS on ion channels including potassium and sodium channels and exogenous glutamate-activated current in cultured rat hippocampal neurons were examined, based on whole-cell patch-clamp recording. PFOS markedly increased two subtypes of potassium currents, including transient outward current and delayed rectifier current, at doses over 10 mu M. PFOS did not affect the amplitude of sodium current at all administrated doses (1, 10 or 100 mu M) but clearly shifted the activation current-voltage curve toward negatively potential. Further. PFOS significantly altered the glutamate-activated current at all doses. Taken together these findings indicated that PFOS disturbs the neuronal physiological processes, which revealed the damage of this pollutant to nerve system and will be helpful for further exploration to its underlying mechanism. (C) 2009 Published by Elsevier B.V. |
| 学科主题 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| 资助信息 | National Natural Science Foundation of China; National Basic Research Program of China; Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1661]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,et al. Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):338-344. |
| APA | Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,Duan, Shu-min,&Jiang, Gui-bin.(2009).Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(3),338-344. |
| MLA | Liao, Chun-yang,et al."Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.3(2009):338-344. |
入库方式： OAI收割
来源：上海神经科学研究所
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