Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group
文献类型：期刊论文
| 作者 | Liao, Chunyang ; Wang, Thanh ; Cui, Lin ; Zhou, Qunfang ; Duan, Shumin ; Jiang, Guibin |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 43期号:6页码:2099-2104 |
| ISSN号 | 0013-936X |
| 关键词 | JUNCTIONAL INTERCELLULAR COMMUNICATION PERFLUOROOCTANE SULFONATE PERFLUOROALKYL ACIDS HUMAN BLOOD IN-VITRO INHIBITION FLUOROCHEMICALS SURFACTANTS MEMBRANE CHANNEL |
| 通讯作者 | Jiang, GB (reprint author), Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China,gbjiang@rcees.ac.cn |
| 英文摘要 | Scientific and public concerns on perfluorinated compounds (PFCs) are increasingly growing because of their environmental persistency, bioaccumulation, and extensive distribution throughout the world. Little is known about the effects of PFCs on neural function and the underlying mechanisms. Recent evidence suggests that the toxicological effects of PFCs are closely correlated with their carbon chain lengths. In this present work, the actions of PFCs with varying chain length on cultured rat hippocampal neurons and possible action patterns were examined. Increases in the frequencies of spontaneous miniature postsynaptic current (mPSC) were commonly found in cultured neurons when perfused with PFCs. The increase of mPSC frequency was in proportion to the carbon chain length, and the potency of perfluorinated carboxylates was less pronounced than that of perfluorinated sulfonates. A comparable but less perceptible trend was also found for the amplitudes of voltage-dependent calcium current (I(ca)). No regular change in pattern was observed for the effects of PFCs on activation and inactivation kinetics of I(Ca). Furthermore, prolonged treatment of PFCs inhibited the neurite growth of neurons to various degrees. Comparisons between nonfluorinated and perfluorinated analogues demonstrated that the fluorination in alkyl chain exerts stronger actions on neurons as compared to the surfactant activity. This study shows that PFCs exhibit adverse effects on cultured neurons to various extents, which is dependent on the carbon chain length and functional group attached to the fully fluorinated alkyl chain. |
| 学科主题 | Engineering ; Environmental Sciences & Ecology |
| 资助信息 | National Basic Research Program of China[2009CB421600]; National Natural Science Foundation of China[20897010, 20621703] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1672]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liao, Chunyang,Wang, Thanh,Cui, Lin,et al. Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2009,43(6):2099-2104. |
| APA | Liao, Chunyang,Wang, Thanh,Cui, Lin,Zhou, Qunfang,Duan, Shumin,&Jiang, Guibin.(2009).Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group.ENVIRONMENTAL SCIENCE & TECHNOLOGY,43(6),2099-2104. |
| MLA | Liao, Chunyang,et al."Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group".ENVIRONMENTAL SCIENCE & TECHNOLOGY 43.6(2009):2099-2104. |
入库方式： OAI收割
来源：上海神经科学研究所
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