Erythropoietin Inhibits the Increase of Intestinal Labile Zinc and the Expression of Inflammatory Mediators After Traumatic Brain Injury in Rats
文献类型：期刊论文
| 作者 | Zhu, Lin ; Jin, Wei ; Pan, Hao ; Hu, Zelan ; Zhou, Jing ; Hang, Chunhua ; Shi, Jixin |
| 刊名 | JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
 |
| 出版日期 | 2009 |
| 卷号 | 66期号:3页码:730-736 |
| 关键词 | Traumatic brain injury Intestine Erythropoietin Zinc Cytokines NF-KAPPA-B MULTIPLE ORGAN FAILURE SUBARACHNOID HEMORRHAGE CARDIAC-ARRHYTHMIAS HYDROXYETHYL STARCH NEURONAL APOPTOSIS CEREBRAL-ISCHEMIA ENDOTOXIC RATS BOWEL-DISEASE FREE-RADICALS |
| ISSN号 | 0022-5282 |
| 通讯作者 | Shi, JX (reprint author), Nanjing Univ, Dept Neurosurg, Jinling Hosp, Sch Med, 305 E Zhongshan Rd, Nanjing 210002, Jiangsu Prov, Peoples R China,shijixin52@163.com |
| 英文摘要 | Background: The objective of this study was to determine the effect of erythropoietin (Epo) on the intestinal labile zinc and the inflammatory factor in rats after traumatic brain injury (TBI). Methods: Male Sprague-Dawley rats were randomly divided into nine groups: (a) normal group; (b) sham-operation group; (c, d, e, f, and g) TBI group, killed at I hour, 6 hour, 24 hour, and 72 hour and 7 days postinjury, respectively; (h and i) TBI + saline and TBI + Epo, killed at 24 hour or 72 hour postinjury. Parietal brain contusion was produced by a free-falling weight on the exposed dura of the right parietal lobe. Intestinal labile zinc, the tumor necrosis factor-a, interleukin (IL)-8, and wet/dry weight ratio were investigated in different groups. Results: The gut contains a certain amount of labile zinc in normal animals and TBI caused obviously gradual increment of intestinal liabled zinc. The levels of inflammatory mediators and the gut wet/dry weight ratio were also found to increase in the trauma group (p < 0.05). There was a highly positive correlation between the abundance of zinc fluorescence and these proinflammation factors. Epo significantly reduced the intestinal labile zinc, the inflammatory mediators, and the gut wet/dry weight ratio compared with TBI group (p < 0.05). Conclusions: Epo can protect intestine from TBI-induced injury by attenuating intestinal inflammation and labile zinc accumulation in vivo. |
| 学科主题 | General & Internal Medicine ; Surgery |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1673]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhu, Lin,Jin, Wei,Pan, Hao,et al. Erythropoietin Inhibits the Increase of Intestinal Labile Zinc and the Expression of Inflammatory Mediators After Traumatic Brain Injury in Rats[J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE,2009,66(3):730-736. |
| APA | Zhu, Lin.,Jin, Wei.,Pan, Hao.,Hu, Zelan.,Zhou, Jing.,...&Shi, Jixin.(2009).Erythropoietin Inhibits the Increase of Intestinal Labile Zinc and the Expression of Inflammatory Mediators After Traumatic Brain Injury in Rats.JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE,66(3),730-736. |
| MLA | Zhu, Lin,et al."Erythropoietin Inhibits the Increase of Intestinal Labile Zinc and the Expression of Inflammatory Mediators After Traumatic Brain Injury in Rats".JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 66.3(2009):730-736. |
入库方式： OAI收割
来源：上海神经科学研究所
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