Transient receptor potential channel C3 contributes to the progression of human ovarian cancer
文献类型：期刊论文
| 作者 | Yang, S. L. ; Cao, Q. ; Zhou, K. C. ; Feng, Y. J. ; Wang, Y. Z. |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2009 |
| 卷号 | 28期号:10页码:1320-1328 |
| ISSN号 | 0950-9232 |
| 关键词 | TRPC channels ovarian epithelium cancer proliferation Ca(2+)/calmodulin-dependent kinase II M phase CAPACITATIVE CA2+ ENTRY PROTEIN KINASE-II CELL-PROLIFERATION MAMMALIAN-CELLS TRPC3 CHANNELS CYTOSTATIC FACTOR EPITHELIAL-CELLS CALCIUM EXPRESSION ACTIVATION |
| 通讯作者 | Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | Ovarian cancer (OC) is the leading cause of death from gynecological malignancy. However, the mechanism by which OC develops remains largely unknown. Increases in cytosolic free Ca(2+) ([Ca(2+)](i)) can result in different physiological changes including cell growth, differentiation and death. The transient receptor potential (TRP) C channels are nonselective cation channels with permeability to Ca2(+). Here we report that TRPC3 channels promote human OC growth. The TRPC3 protein levels in human OC specimens were greatly increased than those in normal ovarian specimens. Downregulating TRPC3 expression in SKOV3 cells, a human OC cell line, led to reduction of proliferation, suppression in epidermal growth factor-induced Ca(2+) in flux, dephosphorylation of Cdc2 and CaMKII alpha and prolonged progression through M phase of these cells. Further, decreased the expression of TRPC3 suppressed the tumor formation generated by injecting SKOV3 cells in nude mice. Together, our results suggest that increased activity of TRPC3 channels is necessary for the development of OCs. Oncogene (2009) 28, 1320-1328; doi:10.1038/onc.2008.475; published online 19 January 2009 |
| 学科主题 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 资助信息 | 973 Program[2006CB806600]; National Natural Science Foundation of China[30711120566, 30621062, U0632006] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1674]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yang, S. L.,Cao, Q.,Zhou, K. C.,et al. Transient receptor potential channel C3 contributes to the progression of human ovarian cancer[J]. ONCOGENE,2009,28(10):1320-1328. |
| APA | Yang, S. L.,Cao, Q.,Zhou, K. C.,Feng, Y. J.,&Wang, Y. Z..(2009).Transient receptor potential channel C3 contributes to the progression of human ovarian cancer.ONCOGENE,28(10),1320-1328. |
| MLA | Yang, S. L.,et al."Transient receptor potential channel C3 contributes to the progression of human ovarian cancer".ONCOGENE 28.10(2009):1320-1328. |
入库方式： OAI收割
来源：上海神经科学研究所
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