Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina
文献类型：期刊论文
| 作者 | Chen, Minggang ; Weng, Shijun ; Deng, Qiudong ; Xu, Zhen ; He, Shigang |
| 刊名 | JOURNAL OF PHYSIOLOGY-LONDON
 |
| 出版日期 | 2009 |
| 卷号 | 587期号:4页码:819-828 |
| 关键词 | STARBURST AMACRINE CELLS RABBIT RETINA VISUAL EXPERIENCE MORPHOLOGICAL PROPERTIES INNER RETINA MATURATION DENDRITES SYNAPSE STIMULATION SENSITIVITY |
| ISSN号 | 0022-3751 |
| 通讯作者 | He, SG (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, 15 Da Tun Rd, Beijing 100101, Peoples R China,shiganghe@moon.ibp.ac.cn |
| 英文摘要 | Selective responses of retinal ganglion cells (RGCs) to the direction of motion have been recorded extracellularly from the rabbit and the mouse retina at eye opening. Recently, it has been shown that the development of this circuitry is light independent. Using whole-cell patch clamp recording, we report here that mouse early postnatal direction-selective ganglion cells (DSGCs) showed lower membrane excitability, lower reliability of synaptic transmission and much slower kinetics of light responses compared with adult DSGCs. However, the degree of direction selectivity of early postnatal DSGCs measured by the direction-selective index and the width of the directional tuning curve was almost identical to that of adult DSGCs. The DSGCs exhibited a clear selectivity for the direction of motion at the onset of light sensitivity. Furthermore, the degree of direction selectivity was not affected by rearing in complete darkness from birth to postnatal day 11 or 30. The formation of the retinal neurocircuitry for coding motion direction is completely independent of light. |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China key project[30530280]; National Basic Research Program of China[2007CB512208, 2006CB911003] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1679]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, Minggang,Weng, Shijun,Deng, Qiudong,et al. Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina[J]. JOURNAL OF PHYSIOLOGY-LONDON,2009,587(4):819-828. |
| APA | Chen, Minggang,Weng, Shijun,Deng, Qiudong,Xu, Zhen,&He, Shigang.(2009).Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina.JOURNAL OF PHYSIOLOGY-LONDON,587(4),819-828. |
| MLA | Chen, Minggang,et al."Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina".JOURNAL OF PHYSIOLOGY-LONDON 587.4(2009):819-828. |
入库方式： OAI收割
来源：上海神经科学研究所
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