Cytokine-induced Suppression of Medial Preoptic Neurons Mechanisms and Neuroimmunomodulatory Effects
文献类型：期刊论文
| 作者 | Katafuchi, Toshihiko ; Duan, Shumin ; Take, Sachiko ; Yoshimuraa, Megumu |
| 刊名 | NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY
 |
| 出版日期 | 2009 |
| 卷号 | 1153页码:76-81 |
| 关键词 | medial preoptic area natural killer cell splenic sympathetic nerve patch clamp NMDA calcium-activated K(+) channel NATURAL-KILLER CYTOTOXICITY SYMPATHETIC-NERVOUS-SYSTEM CENTRAL INTERLEUKIN-1-BETA CORTICAL-NEURONS GLUTAMATE RATS INTERFERON MODULATION AREA |
| ISSN号 | 0077-8923 |
| 通讯作者 | Katafuchi, T (reprint author), Kyushu Univ, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 8128582, Japan,kataf@physiol.med.kyushu-u.ac.up |
| 英文摘要 | We have shown that the medial preoptic area (MPO) in the hypothalamus is a major site where interferon (IFN)-alpha acts to induce suppression of splenic natural killer (NK) cell activity through an activation of sympathetic nervous system (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine action using in vivo and in vitro preparations in rats. Lesion of the MPO activated the SNS and suppressed splenic NK cell activity in anesthetized rats, suggesting that the MPO had an inhibitory influence on nerve activity. Since both IFN-alpha and interleukin (IL)-1 beta are known to suppress MPO neuron activity, it is suggested that the suppression/loss of the MPO caused by cytokine actions/lesions disinhibits the hypothalamic-sympathetic pathway, thereby resulting in an increase in the splenic SNS and reduction of NK activity. To explore the cellular mechanisms of the suppression of MPO neurons, the effects of Prostaglandin E(2) (PGE(2)), one of the major mediators of cytokine action in the brain, on the glutamate-induced membrane currents were examined using the perforated patch-clamp method in mechanically dissociated MPO neurons. Patch-clamp analysis revealed that PGE(2) potentiated the Ca(2+)-dependent K(+) current (KCa) stimulated by Ca(2+) entry through N-methyl-D-aspartate channels. We suggest that the cytokine-induced decrease in the firing rates of MPO neurons may be a result of an increase in interspike intervals caused by PGE(2)-induced enhancement of KCa in the presence of glutamatergic inputs. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Ministry of Education, Culture, Sports, Science and Technology[19603004]; Japanese Government |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1687]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Katafuchi, Toshihiko,Duan, Shumin,Take, Sachiko,et al. Cytokine-induced Suppression of Medial Preoptic Neurons Mechanisms and Neuroimmunomodulatory Effects[J]. NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY,2009,1153:76-81. |
| APA | Katafuchi, Toshihiko,Duan, Shumin,Take, Sachiko,&Yoshimuraa, Megumu.(2009).Cytokine-induced Suppression of Medial Preoptic Neurons Mechanisms and Neuroimmunomodulatory Effects.NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY,1153,76-81. |
| MLA | Katafuchi, Toshihiko,et al."Cytokine-induced Suppression of Medial Preoptic Neurons Mechanisms and Neuroimmunomodulatory Effects".NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY 1153(2009):76-81. |
入库方式： OAI收割
来源：上海神经科学研究所
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