Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions
文献类型：期刊论文
| 作者 | Samson, Willis K. ; Zhang, Jian V. ; Avsian-Kretchmer, Orna ; Cui, Kai ; Yosten, Gina L. C. ; Klein, Cindy ; Lyu, Rong-Ming ; Wang, Yong Xiong ; Chen, Xiang Qun ; Yang, Jun ; Price, Christopher J. ; Hoyda, Ted D. ; Ferguson, Alastair V. ; Yuan, Xiao-bin ; Chang, Jaw Kang ; Hsueh, Aaron J. W. |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 283期号:46页码:31949-31959 |
| 关键词 | CENTRAL-NERVOUS-SYSTEM GROWTH-HORMONE FOOD-INTAKE C-FOS MOLECULAR-BIOLOGY BLOOD-PRESSURE SECRETION RECEPTORS PEPTIDE BRAIN |
| ISSN号 | 0021-9258 |
| 通讯作者 | Samson, WK (reprint author), St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA,samsonwk@slu.edu ; aaron.hsueh@stanford.edu |
| 英文摘要 | Somatostatin is important in the regulation of diverse neuroendocrine functions. Based on bioinformatic analyses of evolutionarily conserved sequences, we predicted another peptide hormone in pro-somatostatin and named it neuronostatin. Immuno-affinity purification allowed the sequencing of an amidated neuronostatin peptide of 13 residues from porcine tissues. In vivo treatment with neuronostatin induced c-Fos expression in gastrointestinal tissues, anterior pituitary, cerebellum, and hippocampus. In vitro treatment with neuronostatin promoted the migration of cerebellar granule cells and elicited direct depolarizing actions on paraventricular neurons in hypothalamic slices. In a gastric tumor cell line, neuronostatin induced c-Fos expression, stimulated SRE reporter activity, and promoted cell proliferation. Furthermore, intracerebroventricular treatment with neuronostatin increased blood pressure but suppressed food intake and water drinking. Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide. |
| 学科主题 | Biochemistry & Molecular Biology |
| 收录类别 | SCI |
| 资助信息 | National Institutes of Health[HL68652, HL66023]; Johnson & Johnson Pharmaceutical Research & Development, L.L.C; Shanghai Institutes of Biological Sciences |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1691]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Samson, Willis K.,Zhang, Jian V.,Avsian-Kretchmer, Orna,et al. Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2008,283(46):31949-31959. |
| APA | Samson, Willis K..,Zhang, Jian V..,Avsian-Kretchmer, Orna.,Cui, Kai.,Yosten, Gina L. C..,...&Hsueh, Aaron J. W..(2008).Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions.JOURNAL OF BIOLOGICAL CHEMISTRY,283(46),31949-31959. |
| MLA | Samson, Willis K.,et al."Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions".JOURNAL OF BIOLOGICAL CHEMISTRY 283.46(2008):31949-31959. |
入库方式： OAI收割
来源：上海神经科学研究所
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