TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis
文献类型：期刊论文
| 作者 | Luo, Zhen-Ge
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2008 |
| 卷号 | 105期号:44页码:17181-17186 |
| 关键词 | BDNF dendrite neuronal activity Rac prenylation RHO-GTPASES NMDA-RECEPTOR PRENYLATED PROTEINS ACTIN CYTOSKELETON NEURITE OUTGROWTH NEURONAL-ACTIVITY GENE-EXPRESSION BETA-CATENIN GROWTH HIPPOCAMPAL |
| ISSN号 | 0027-8424 |
| 通讯作者 | Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn |
| 英文摘要 | Dendrite morphogenesis is regulated by neuronal activity or neurotrophins, which may function by activating intrinsic signaling proteins, including Rho family GTPases. Here we report that activity- and brain-derived neurotrophic factor (BDNF)- dependent dendritic morphogenesis requires activation of geranylgeranyltransferase I (GGT), a prenyltransferase that mediates lipid modification of Rho GTPases. Dendritic arborization in cultured hippocampal neurons was promoted by over-expression of GGT, and reduced by inhibition or down-regulation of GGT. Furthermore, GGT was activated by neuronal depolarization or BDNF, both of which promote dendritic arborization, in cultured hippocampal neurons. Moreover, exploration of a novel environment caused activation of GGT in the mice hippocampus, suggesting that neural activity activates GGT in vivo. Interestingly, GGT was physically associated with tropomyosin-related kinase B (TrkB), the receptor for BDNF, and this association was enhanced by depolarization. Disrupting the GGT-TrkB interaction or down-regulating GGT activity attenuated depolarization- or BDNF-induced dendrite development. Finally, the GGT effect on dendrite arborization was prevented by over-expressing Rac1 with the prenylation site deleted or mutated. Thus depolarization- or BDNF-dependent dendrite development may be mediated by GGT-induced prenylation of Rho GTPases. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30721004, 30825013]; "973" Program and Key State Research Program of China[2006CB806600, 2006CB943900]; Chinese Academy of Sciences[KSCX2-YW-R-102]; Program of Shanghai Subject Chief Scientist[08XD14050] |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1693]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_突触信号研究组 |
| 推荐引用方式 GB/T 7714 | Luo, Zhen-Ge. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2008,105(44):17181-17186. |
| APA | Luo, Zhen-Ge.(2008).TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,105(44),17181-17186. |
| MLA | Luo, Zhen-Ge."TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.44(2008):17181-17186. |
入库方式： OAI收割
来源：上海神经科学研究所
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