DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain
文献类型：期刊论文
| 作者 | Shi, Ming ; Guo, Chao ; Dai, Jin-Xia ; Ding, Yu-Qiang |
| 刊名 | MOLECULAR AND CELLULAR NEUROSCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 39期号:4页码:529-538 |
| 关键词 | DCC Netrin Locus coeruleus Tangential migration Alar plate Rhombomere 1 Development AXON GUIDANCE COLORECTAL-CANCER SEROTONERGIC NEURONS NERVOUS-SYSTEM SPINAL-CORD NETRIN RECEPTOR SENSORY NEURONS GENE-PRODUCT PROTEIN DIFFERENTIATION |
| ISSN号 | 1044-7431 |
| 通讯作者 | Ding, YQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn |
| 英文摘要 | The tangential migration from the dorsal rhombomere (r) 1 to the dorsolateral pontine tegmentum is a crucial event in the development of locus coeruleus (LC), but the molecular mechanisms underlying the migration are not well Understood. We show that the Netrin receptor DCC is expressed in LC neurons and is required for their tangential migration. In DCC(-/-) embryos, fate determination of LC neurons appeared normal but tangential migration failed to initiate properly. Although many LC neurons eventually reached the a Substantial number of LC dorsolateral pontine tegmentum in DCC(-/-) embryos at late embryonic stages, neurons were abnormally distributed in the rostral pons and cerebellum. In DCC(kanga) mice that lack the intracellular P3 domain of DCC, these defects were not observed. In addition, although Unc5h3, another Netrin receptor, was expressed in the dorsal r1, Unc5h3(-/-) mice exhibited the normal LC morphology and gene expression profiles in the LC compared with wild-type mice. Thus, our findings demonstrate that DCC is a key regulator of tangential migration of LC neurons during the embryonic development. (C) 2008 Published by Elsevier Inc. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30525014, 30628016, 30570637]; Ministry of Science and Technology of China[2006CB806601, 2006CB500808, 2007CB512303]; Chinese Academy of Sciences[KSCX2-YW-R-35, KSCX2-YW-R-100] |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1694]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Shi, Ming,Guo, Chao,Dai, Jin-Xia,et al. DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain[J]. MOLECULAR AND CELLULAR NEUROSCIENCE,2008,39(4):529-538. |
| APA | Shi, Ming,Guo, Chao,Dai, Jin-Xia,&Ding, Yu-Qiang.(2008).DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain.MOLECULAR AND CELLULAR NEUROSCIENCE,39(4),529-538. |
| MLA | Shi, Ming,et al."DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain".MOLECULAR AND CELLULAR NEUROSCIENCE 39.4(2008):529-538. |
入库方式： OAI收割
来源：上海神经科学研究所
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