Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval
文献类型：期刊论文
| 作者 | Wang, Wei
|
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2008 |
| 卷号 | 18期号:10页码:2391-2401 |
| 关键词 | D-serine glia hippocampus long-term depression memory retrieval NMDA receptor METHYL-D-ASPARTATE SYNAPTIC PLASTICITY NUCLEUS-ACCUMBENS RECEPTOR BRAIN GLIA POTENTIATION RACEMASE SLICES NEUROTRANSMISSION |
| ISSN号 | 1047-3211 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | D-Serine, the endogenous coagonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be an important gliotransmitter, and is essential for the induction of long-term potentiation. However, less is known about the role of D-serine in another form of synaptic plasticity, long-term depression (LTD). In this study, we found that exogenous D-serine regulated LTD in the hippocampal CA1 region in a "bell-shaped" concentration-dependent manner through regulating the function of NMDARs in the same manner, whereas endogenous D-serine was activity-dependently released and, in turn, contributed to the induction of LTD during low-frequency stimulation. Furthermore, impairing glial functions with sodium fluoroacetate (NaFAC) reduced the magnitude of LTD, which could be restored by exogenous D-serine, indicating that endogenous D-serine is mainly glia-derived during LTD induction. More interestingly, similar to the effects on LTD, exogenous D-serine enhanced spatial memory retrieval in the Morris water maze in a bell-shaped dose-dependent manner and rescued the NaFAC-induced impairment of memory retrieval, suggesting links between LTD and spatial memory retrieval. Our study thus provides direct evidence of the bell-shaped D-serine actions on hippocampal LTD and spatial memory retrieval, and underscores the importance of D-serine in synaptic plasticity, learning, and memory. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30621062]; National Basic Research Program of China[2006CB500803]; Chinese Academy of Sciences[KSCX2-YW-R-35] |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1697]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_视知觉机制研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Wei. Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval[J]. CEREBRAL CORTEX,2008,18(10):2391-2401. |
| APA | Wang, Wei.(2008).Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval.CEREBRAL CORTEX,18(10),2391-2401. |
| MLA | Wang, Wei."Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval".CEREBRAL CORTEX 18.10(2008):2391-2401. |
入库方式： OAI收割
来源：上海神经科学研究所
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