Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors
文献类型：期刊论文
| 作者 | Yang, Chuan-Xiu ; Zhang, Xiao-Bing ; Gong, Neng ; Wang, Meng-Ya ; Xu, Tian-Le(徐天乐) |
| 刊名 | NEUROCHEMICAL RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 33期号:10页码:2159-2165 |
| 关键词 | thiopental pentobarbital GABA(A) receptors mechanically dissociated neuron spinal cord dorsal horn GATED ION CHANNELS DORSAL-HORN NEURONS IN-VITRO ETOMIDATE ANESTHETICS MODULATION ACTIVATION MECHANISMS SUBUNIT SITES |
| ISSN号 | 0364-3190 |
| 通讯作者 | Xu, TL (reprint author), Med Coll Soochow Univ, Dept Neurobiol, 199 Ren Ai Rd,Suzhou Ind Pk, Suzhou 215123, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | General anesthetics thiopental and pentobarbital possess very similar chemical structures whereas their clinical potency is quite different. The underlying molecular mechanism is not fully understood. This study was designed to assess the differential effects of thiopental and pentobarbital on GABA(A) receptors of mechanically dissociated rat spinal dorsal horn neurons by using whole-cell patch-clamp technique. Pentobarbital, at a concentration of 30 mu M, which markedly enhanced sub-saturated GABA-induced current (I (GABA)), had no effect on thiopental-induced maximal current. Similarly, the pentobarbital-induced maximal current was also not affected by 30 mu M thiopental. Moreover, a linear summation of thiopental-induced maximal current and pentobarbital-induced sub-maximal current was observed. In addition, pentobarbital failed to further enhance I (GABA) in the presence of thiopental at a concentration with maximal modulatory effects on I (GABA), and vice versa. Our results thus suggest that thiopental and pentobarbital might exert the GABA mimetic effects independently, but share a common mechanism to produce the GABA modulatory effects. |
| 学科主题 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30621062]; National Basic Research Program of China[2006CB500803]; Chinese Academy of Sciences[KSCX2-YW-R-35] |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1700]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yang, Chuan-Xiu,Zhang, Xiao-Bing,Gong, Neng,et al. Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2159-2165. |
| APA | Yang, Chuan-Xiu,Zhang, Xiao-Bing,Gong, Neng,Wang, Meng-Ya,&Xu, Tian-Le.(2008).Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors.NEUROCHEMICAL RESEARCH,33(10),2159-2165. |
| MLA | Yang, Chuan-Xiu,et al."Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors".NEUROCHEMICAL RESEARCH 33.10(2008):2159-2165. |
入库方式： OAI收割
来源：上海神经科学研究所
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