Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics
文献类型：期刊论文
| 作者 | Shu, Yousheng
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:29页码:7260-7272 |
| ISSN号 | 0270-6474 |
| 关键词 | axon kink Hodgkin-Huxley pyramidal cell spike timing Na+ channels NEURONS IN-VIVO AXON INITIAL SEGMENT NEOCORTICAL PYRAMIDAL NEURONS SYNAPTIC CONDUCTANCES COINCIDENCE DETECTION CELLS CHANNELS MODEL DENDRITES CORTEX |
| 通讯作者 | McCormick, DA (reprint author), Yale Univ, Sch Med, Kavli Inst Neurosci, Dept Neurobiol, 333 Cedar St, New Haven, CT 06510 USA,david.mccormick@yale.edu |
| 英文摘要 | Neocortical action potential responses in vivo are characterized by considerable threshold variability, and thus timing and rate variability, even under seemingly identical conditions. This finding suggests that cortical ensembles are required for accurate sensorimotor integration and processing. Intracellularly, trial-to-trial variability results not only from variation in synaptic activities, but also in the transformation of these into patterns of action potentials. Through simultaneous axonal and somatic recordings and computational simulations, we demonstrate that the initiation of action potentials in the axon initial segment followed by backpropagation of these spikes throughout the neuron results in a distortion of the relationship between the timing of synaptic and action potential events. In addition, this backpropagation also results in an unusually high rate of rise of membrane potential at the foot of the action potential. The distortion of the relationship between the amplitude time course of synaptic inputs and action potential output caused by spike backpropagation results in the appearance of high spike threshold variability at the level of the soma. At the point of spike initiation, the axon initial segment, threshold variability is considerably less. Our results indicate that spike generation in cortical neurons is largely as expected by Hodgkin-Huxley theory and is more precise than previously thought. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1712]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组 |
| 推荐引用方式 GB/T 7714 | Shu, Yousheng. Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics[J]. JOURNAL OF NEUROSCIENCE,2008,28(29):7260-7272. |
| APA | Shu, Yousheng.(2008).Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.JOURNAL OF NEUROSCIENCE,28(29),7260-7272. |
| MLA | Shu, Yousheng."Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics".JOURNAL OF NEUROSCIENCE 28.29(2008):7260-7272. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。