Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila
文献类型：期刊论文
| 作者 | Zhang, Shixing ; Yin, Yan ; Lu, Huimin ; Guo, Aike |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008 |
| 卷号 | 370期号:1页码:82-86 |
| 关键词 | drosophila dopamine olfactory memory NEURONS MELANOGASTER TRANSPORTER ACTIVATION EXPRESSION COCAINE |
| ISSN号 | 0006-291X |
| 通讯作者 | Guo, A (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd,Chaoyang Dist, Beijing 100101, Peoples R China,akguo@ion.ac.cn |
| 英文摘要 | Dopamine is necessary for the aversive olfactory associative memory formation in Drosophila, but its effect on other stages of memory is not known. Herein, we studied the effect of enhanced dopaminergic signaling on aversive olfactory memory retention in flies. We used L-3,4-dihydroxyphenylalanine (L-DOPA) to elevate dopamine levels: L-DOPA-treated flies exhibited a normal learning performance, but a decrease in I-h memory. Dopamine transporter (DAT) mutant flies or flies treated with the DAT inhibitor desipramine exhibited poor memory retention, Flies subjected to heat stress after training exhibited a decrease in memory. Memory was restored by blocking dopaminergic neuronal output during heat stress, suggesting that dopamine is involved in heat stress-induced memory impairment in flies. Taken together, our findings suggest that increased dopaminergic signaling impairs aversive olfactory memory retention in flies. (c) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1727]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, Shixing,Yin, Yan,Lu, Huimin,et al. Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,370(1):82-86. |
| APA | Zhang, Shixing,Yin, Yan,Lu, Huimin,&Guo, Aike.(2008).Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,370(1),82-86. |
| MLA | Zhang, Shixing,et al."Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 370.1(2008):82-86. |
入库方式： OAI收割
来源：上海神经科学研究所
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