Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
文献类型：期刊论文
| 作者 | Dong, Zhifang ; Zhong, Weixia ; Tian, Meng ; Han, Huili ; Mao, Rongrong ; Cao, Jun ; Sui, Nan ; Xu, Tianle(徐天乐） ; Luo, Jianhong ; Xu, Lin |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 1207期号:pt 1页码:164-173 |
| 关键词 | opiate withdrawal stress delayed-escape behaviour long-term potentiation NR2A NR2B hippocampus LONG-TERM POTENTIATION ADRENAL-STEROID RECEPTORS SYNAPTIC PLASTICITY SPATIAL MEMORY IN-VIVO NUCLEUS-ACCUMBENS STRESS DEPRESSION ADDICTION RETRIEVAL |
| ISSN号 | 0006-8993 |
| 通讯作者 | Xu, L (reprint author), Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China,lxu@vip.163.com |
| 英文摘要 | Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure. (C) 2008 Elsevier B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1730]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Dong, Zhifang,Zhong, Weixia,Tian, Meng,et al. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio[J]. BRAIN RESEARCH,2008,1207(pt 1):164-173. |
| APA | Dong, Zhifang.,Zhong, Weixia.,Tian, Meng.,Han, Huili.,Mao, Rongrong.,...&Xu, Lin.(2008).Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio.BRAIN RESEARCH,1207(pt 1),164-173. |
| MLA | Dong, Zhifang,et al."Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio".BRAIN RESEARCH 1207.pt 1(2008):164-173. |
入库方式： OAI收割
来源：上海神经科学研究所
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