Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells
文献类型：期刊论文
| 作者 | Yu, Hui-Mei ; Wen, Jing ; Wang, Rong ; Shen, Wan-Hua ; Duan, Shumin ; Yang, Huang-Tian |
| 刊名 | CELL CALCIUM
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:5页码:417-431 |
| 关键词 | neurogenesis ryanodine receptors ES cells L-type Ca2+ channels GABA(A) receptors HIPPOCAMPAL PROGENITOR CELLS CALCIUM-RELEASE CA2+ CHANNELS NEURONAL DIFFERENTIATION ENDOPLASMIC-RETICULUM CARDIAC MYOCYTES SKELETAL-MUSCLE IN-VITRO GABA PROLIFERATION |
| ISSN号 | 0143-4160 |
| 通讯作者 | Yang, HT (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China,htyang@sibs.ac.cn |
| 英文摘要 | Activity-induced neurogenesis via Ca2+ entry may be important for establishing Hebbian neural network. However, it remains unclear whether intracellular Ca2+ mobilization is required and which subtypes of Ca2+ release channels expressed in Ca2+ store organelles are involved in the activity-dependent neurogenesis. Here, we demonstrated that the activity of intracellular Ca2+ signaling, expression of neuronal transcription factor NeuroD, and the rate of neurogenesis were significantly inhibited in neuronal cells derived from embryonic stem (ES) cells deficient in the Ca2+ release channel type 2 ryanodine receptors (RyR2(-/-)). In wild-type (RyR2(+/+)) but not in RyR2(-/-) ES cells, activation of L-type Ca2+ channels, GABA(A) receptors, or RyRs promoted neuronal differentiation, while inhibition of these channels/receptors had an opposite effect. Moreover, neuronal differentiation promoted by activation of GABA(A) receptors or L-type Ca2+ channels in RyR2(+/+) cells was prevented by RyR inhibitors. No significant difference was detected in the expression level of GABA(A) receptors and L-type channels between neuronal cells derived from two types of ES cells. Thus, activity-induced Ca2+ influx through L-type Ca2+ channels alone is not sufficient in promoting neurogenesis. Instead, an intimate cooperation of L-type Ca2+ channels with RyR2 is crucial for the activity-dependent neurogenesis induced by paracrine and/or autocrine GABA signaling. (c) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1731]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yu, Hui-Mei,Wen, Jing,Wang, Rong,et al. Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells[J]. CELL CALCIUM,2008,43(5):417-431. |
| APA | Yu, Hui-Mei,Wen, Jing,Wang, Rong,Shen, Wan-Hua,Duan, Shumin,&Yang, Huang-Tian.(2008).Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells.CELL CALCIUM,43(5),417-431. |
| MLA | Yu, Hui-Mei,et al."Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells".CELL CALCIUM 43.5(2008):417-431. |
入库方式： OAI收割
来源：上海神经科学研究所
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