Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay
文献类型：期刊论文
| 作者 | Huang, Zhi-hui ; Wang, Ying ; Cao, Li ; Su, Zhi-da ; Zhu, Yan-ling ; Chen, Yi-zhang ; Yuan, Xiao-bing ; He, Cheng |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 18期号:4页码:479-490 |
| 关键词 | olfactory ensheathing cells motility morphology LPA single-cell migration RAT SPINAL-CORD IN-VITRO AXONAL REGENERATION GLIA TRANSPLANTS SPATIOTEMPORAL PATTERNS MORPHOLOGICAL ASPECTS NEURONAL MIGRATION NEURITE OUTGROWTH LAMINA-PROPRIA NGF-RECEPTOR |
| ISSN号 | 1001-0602 |
| 通讯作者 | He, C (reprint author), Zhejiang Univ, Sch Med, Dept Neurobiol, Inst Neurosci, Hangzhou 310058, Zhejiang, Peoples R China,chenghe@online.sh.cn |
| 英文摘要 | Olfactory ensheathing cells (OECs) are a unique type of glial cells that have axonal growth-promoting properties. OEC transplantation has emerged as a promising experimental therapy of axonal injuries and demyelinating diseases. However, some fundamental cellular properties of OECs remain unclear. In this study, we found that the distinct OEC subpopulations exhibited different migratory properties based on time-lapse imaging of single isolated cells, possibly due to their different cytoskeletal organizations. Moreover, OEC subpopulations displayed different attractive migratory responses to a gradient of lysophosphatidic acid (LPA) in single-cell migration assays. Finally, we found that OEC subpopulations transformed into each other spontaneously. Together, these results demonstrate, for the first time to our knowledge, that distinct OEC subpopulations display different migratory properties in vitro and provide new evidence to support the notion of OECs as a single cell type with malleable functional phenotypes. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1733]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Huang, Zhi-hui,Wang, Ying,Cao, Li,et al. Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay[J]. CELL RESEARCH,2008,18(4):479-490. |
| APA | Huang, Zhi-hui.,Wang, Ying.,Cao, Li.,Su, Zhi-da.,Zhu, Yan-ling.,...&He, Cheng.(2008).Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay.CELL RESEARCH,18(4),479-490. |
| MLA | Huang, Zhi-hui,et al."Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay".CELL RESEARCH 18.4(2008):479-490. |
入库方式： OAI收割
来源：上海神经科学研究所
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