Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin
文献类型：期刊论文
| 作者 | Zhu, Dan ; Yang, Zhihua ; Luo, Zhenge ; Luo, Shiwen ; Xiong, Wen C. ; Mei, Lin |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:7页码:1688-1696 |
| 关键词 | neuromuscular junction nicotinic acetylcholine receptors agrin endocytosis MuSK NSF JUNCTION IN-VIVO SENSITIVE FUSION PROTEIN NEUROMUSCULAR-JUNCTION SIGNAL-TRANSDUCTION MEDIATED ENDOCYTOSIS TRANSPORT VESICLES PLASMA-MEMBRANE CLATHRIN MUSK CAVEOLAE |
| ISSN号 | 0270-6474 |
| 通讯作者 | Mei, L (reprint author), Med Coll Georgia, Inst Mol Med & Genet, Program Dev Neurobiol, 1120 15th St, Augusta, GA 30912 USA,lmei@mcg.edu |
| 英文摘要 | Agrin, a factor used by motoneurons to direct acetylcholine receptor (AChR) clustering at the neuromuscular junction, initiates signal transduction by activating the muscle-specific receptor tyrosine kinase (MuSK). However, the underlying mechanisms remain poorly defined. Here, we demonstrated that MuSK became rapidly internalized in response to agrin, which appeared to be required for induced AChR clustering. Moreover, we provided evidence for a role of N-ethylmaleimide sensitive factor (NSF) in regulating MuSK endocytosis and subsequent signaling in response to agrin stimulation. NSF interacts directly with MuSK with nanomolar affinity, and treatment of muscle cells with the NSF inhibitor N-ethylmaleimide, mutation of NSF, or suppression of NSF expression all inhibited agrin-induced AChR clustering. Furthermore, suppression of NSF expression and NSF mutation attenuate MuSK downstream signaling. Our study reveals a potentially novel mechanism that regulates agrin/MuSK signaling cascade. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1738]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhu, Dan,Yang, Zhihua,Luo, Zhenge,et al. Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin[J]. JOURNAL OF NEUROSCIENCE,2008,28(7):1688-1696. |
| APA | Zhu, Dan,Yang, Zhihua,Luo, Zhenge,Luo, Shiwen,Xiong, Wen C.,&Mei, Lin.(2008).Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin.JOURNAL OF NEUROSCIENCE,28(7),1688-1696. |
| MLA | Zhu, Dan,et al."Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin".JOURNAL OF NEUROSCIENCE 28.7(2008):1688-1696. |
入库方式： OAI收割
来源：上海神经科学研究所
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