Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage
文献类型：期刊论文
| 作者 | Na Zhao ; Chunjiu Zhong ; Yang Wang ; Yanling Zhao ; Neng Gong ; Guomin Zhou ; Tianle Xu ; Zhen Hong |
| 刊名 | NEUROBIOLOGY OF DISEASE
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:2页码:176-185 |
| 关键词 | thiamine deficiency learning and memory hippocampal neurogenesis mouse ADULT NEUROGENESIS DENTATE GYRUS ENHANCES NEUROGENESIS ALZHEIMERS-DISEASE NERVOUS-SYSTEM BORN NEURONS BRAIN RAT MEMORY MODEL |
| ISSN号 | 0969-9961 |
| 通讯作者 | Zhong, CJ (reprint author), Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai, Peoples R China,zhongcj@163.com ; hongzhen@medmail.com.cn |
| 英文摘要 | It has not been reported whether thiamine deficiency (TD) affects hippocampal neurogenesis or not. Here, we explored the influence of TD at early pre-pathological lesion stage on hippocampal neurogenesis and the correlation between affected hippocampal neurogenesis and cognitive dysfunction. We prepared TD mouse model by feeding a thiamine-depleted diet. Learning and memory functions of TD mice were tested with Y-maze. Hippocampal neurogenesis was studied with BrdU, PCNA, Dcx, and NeuN immunohistochemical staining. The results showed significant decline in learning ability and hippocampal neurogenesis simultaneously since 9-days of treatment when the model mice did not exhibit regular pathological lesion, the loss of cholinergic neurons, decrease of NeuN-positive hippocampal cell, and abnormal long-term potentiation of hippocampal CA1 and CA3. Re-administering thiamine reversed the weakened learning ability as well as the impaired hippocampal neurogenesis induced by TD at early pre-pathological lesion stage. The present study demonstrated that bippocampal neurogenesis was vulnerable to TD and the impaired hippocampal neurogenesis is greatly involved in cognitive dysfunction induced by TD at early pre-pathological lesion stage. (C) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1739]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Na Zhao,Chunjiu Zhong,Yang Wang,et al. Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage[J]. NEUROBIOLOGY OF DISEASE,2008,29(2):176-185. |
| APA | Na Zhao.,Chunjiu Zhong.,Yang Wang.,Yanling Zhao.,Neng Gong.,...&Zhen Hong.(2008).Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage.NEUROBIOLOGY OF DISEASE,29(2),176-185. |
| MLA | Na Zhao,et al."Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage".NEUROBIOLOGY OF DISEASE 29.2(2008):176-185. |
入库方式： OAI收割
来源：上海神经科学研究所
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