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The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition
文献类型：期刊论文
| 作者 | Gong, Neng ; Zhang, Min ; Zhang, Xiao-Bing ; Chen, Lin ; Sun, Guang-Chun ; Xu, Tian-Le(徐天乐) |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 54期号:2页码:454-463 |
| ISSN号 | 0028-3908 |
| 关键词 | aspirin salicylate GABAergic transmission GABA(A) receptor hippocampus population spike NF-KAPPA-B INFERIOR COLLICULUS NEURONS DORSAL-HORN NEURONS SODIUM-SALICYLATE GABA(A) RECEPTORS ACID DYSFUNCTION CHANNELS INTERNEURONS MODULATION |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yue-Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Salicylate is the major metabolite and active component of aspirin (acetylsalicylic acid), which is widely used in clinical medicine for treating inflammation, pain syndromes and cardiovascular disorders. The well-known mechanism underlying salicylate's action mainly involves the inhibition of cyclooxygenase and subsequent decrease in prostaglandin production. Recent evidence suggests that salicylate also affects neuronal function through interaction with specific membrane channels/receptors. However, the effect of salicylate on synaptic and neural network function remains largely unknown. In this study, we investigated the effect of sodium salicylate on the synaptic transmission and neuronal excitation in the hippocampal CA1 area of rats, a key structure for many complex brain functions. With electrophysiological recordings in hippocampal slices, we found that sodium salicylate significantly enhanced neuronal excitation through reducing inhibitory GABAergic transmission without affecting the basal excitatory synaptic transmission. Salicylate significantly inhibited the amplitudes of both evoked and miniature inhibitory postsynaptic currents, and directly reduced gamma-aminobutyric acid type A (GABA(A)) receptor-mediated responses in cultured rat hippocampal neurons. Together, our results suggest that the widely used aspirin might impair hippocampal synaptic and neural network functions through its actions on GABAergic neurotransmission. Given the capability of aspirin to penetrate the blood-brain barrier, the present data imply that aspirin intake may cause network hyperactivity and be potentially harmful in susceptible subpopulations. (C) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1740]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Gong, Neng,Zhang, Min,Zhang, Xiao-Bing,et al. The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition[J]. NEUROPHARMACOLOGY,2008,54(2):454-463. |
| APA | Gong, Neng,Zhang, Min,Zhang, Xiao-Bing,Chen, Lin,Sun, Guang-Chun,&Xu, Tian-Le.(2008).The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition.NEUROPHARMACOLOGY,54(2),454-463. |
| MLA | Gong, Neng,et al."The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition".NEUROPHARMACOLOGY 54.2(2008):454-463. |
入库方式： OAI收割
来源：上海神经科学研究所
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