Guidance of cortical radial migration by gradient of diffusible factors
文献类型：期刊论文
| 作者 | Zheng, Wang ; Yuan, Xiaobing |
| 刊名 | CELL ADHESION & MIGRATION
 |
| 出版日期 | 2008 |
| 卷号 | 2期号:1页码:48-50 |
| 关键词 | radial migration cortex guidance semaphorin diffusible factors growth cone |
| ISSN号 | 1933-6918 |
| 通讯作者 | Yuan, XB (reprint author), Chinese Acad Sci, Inst Neurosci, SIBS, Lab Neural Circuit Dev, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn |
| 英文摘要 | During the development of cerebral cortex, newborn pyramidal neurons originated from the ventricle wall migrate outwardly to the superficial layer of cortex under the guidance of radial glial filaments. Whether this radial migration of young neurons is guided by gradient of diffusible factors or simply driven by a mass action of newly generated neurons at the ventricular zone is entirely unknown, a potential guidance mechanism that has long been overlooked. Our recent study showed that a guidance molecule semaphorin-3A, which is expressed in descending gradient across cortical layers, may serve as a chemoattractive guidance signal for radial migration of newborn cortical neurons toward upper layers. We hypothesize the existence of four groups of extracellular factors that can guide the radial migration of young neurons: (1) attractive factors expressing in superficial layers of cortex, (2) repulsive factors enriched in the ventricular zone, (3) pro-migratory factors uniformly expressed in all cortical layers and (4) stop signals locally expressed in the outmost layer of cortex. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30300103]; Shanghai government[06QH14017] |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1742]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zheng, Wang,Yuan, Xiaobing. Guidance of cortical radial migration by gradient of diffusible factors[J]. CELL ADHESION & MIGRATION,2008,2(1):48-50. |
| APA | Zheng, Wang,&Yuan, Xiaobing.(2008).Guidance of cortical radial migration by gradient of diffusible factors.CELL ADHESION & MIGRATION,2(1),48-50. |
| MLA | Zheng, Wang,et al."Guidance of cortical radial migration by gradient of diffusible factors".CELL ADHESION & MIGRATION 2.1(2008):48-50. |
入库方式： OAI收割
来源：上海神经科学研究所
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