Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron
文献类型：期刊论文
| 作者 | Liao ChunYang ; Duan ShuMin ; Jiang GuiBin |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 51期号:1页码:62-68 |
| 关键词 | polybrominated diphenyl ether (PBDE) neuron neurite synapse development inhibition BROMINATED FLAME RETARDANTS GROWTH CONE EXPOSURE MICE ENVIRONMENT PBDES |
| ISSN号 | 1006-9291 |
| 通讯作者 | Jiang, G (reprint author), Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China,gbjiang@rcees.ac.cn |
| 英文摘要 | Polybrominated diphenyl ether (PBDE) is a persistently environmental pollutant ubiquitously found in wildlife and humans. Although concern on PBDE's toxic effects is steadily increasing, its action on the central nervous system (CNS) remains largely unknown. To address this issue, the present study examined the development inhibition of PBDE in neurons. The primary cultured hippocampal neurons of rat were exposed to the commercial decabromodiphenyl ether (deca-BDE), and the neurite length, bifurcation, and synapse formation and maturation were evaluated, based on the confocal microscope imaging. The results showed that the development inhibition in neurons occurred at 15 mu mol/L, indicating that PBDE is a potent neurotoxicant and it might obviously inhibit the development of cultured neurons. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1745]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liao ChunYang,Duan ShuMin,Jiang GuiBin. Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2008,51(1):62-68. |
| APA | Liao ChunYang,Duan ShuMin,&Jiang GuiBin.(2008).Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron.SCIENCE IN CHINA SERIES B-CHEMISTRY,51(1),62-68. |
| MLA | Liao ChunYang,et al."Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron".SCIENCE IN CHINA SERIES B-CHEMISTRY 51.1(2008):62-68. |
入库方式： OAI收割
来源：上海神经科学研究所
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