Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity
文献类型：期刊论文
| 作者 | Duan, Bo ; Wu, Long-Jun ; Yu, Yao-Qing ; Ding, Yu ; Jing, Liang ; Xu, Lin ; Chen, Jun ; Xu, Tian-Le(徐天乐) |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 27期号:41页码:11139-11148 |
| 关键词 | acid-sensing ion channel spinal dorsal horn calcium sensitization plasticity inflammation chronic pain STIMULATED ADENYLYL CYCLASES BEHAVIORAL SENSITIZATION SYNAPTIC PLASTICITY NMDA RECEPTOR MICE LACKING RAT CALCIUM CORD MECHANISMS EXPRESSION |
| ISSN号 | 0270-6474 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Development of chronic pain involves alterations in peripheral nociceptors as well as elevated neuronal activity in multiple regions of the CNS. Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model. However, the cellular distribution and the functional consequence of increased ASIC subunit expression in the SDH remain unclear. Here, we identify the Ca2+-permeable, homomeric ASIC1a channels as the predominant ASICs in rat SDH neurons and downregulation of ASIC1a by local rat spinal infusion with specific inhibitors or antisense oligonucleotides markedly attenuated complete Freund's adjuvant (CFA)-induced thermal and mechanical hypersensitivity. Moreover, in vivo electrophysiological recording showed that the elevated ASIC1a activity is required for two forms of central sensitization: C-fiber-induced "wind- up" and CFA-induced hypersensitivity of SDH nociceptive neurons. Together, our results reveal that increased ASIC activity in SDH neurons promotes pain by central sensitization. Specific blockade of Ca2+-permeable ASIC1a channels thus may have antinociceptive effect by reducing or preventing the development of central sensitization induced by inflammation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1751]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Duan, Bo,Wu, Long-Jun,Yu, Yao-Qing,et al. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity[J]. JOURNAL OF NEUROSCIENCE,2007,27(41):11139-11148. |
| APA | Duan, Bo.,Wu, Long-Jun.,Yu, Yao-Qing.,Ding, Yu.,Jing, Liang.,...&Xu, Tian-Le.(2007).Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity.JOURNAL OF NEUROSCIENCE,27(41),11139-11148. |
| MLA | Duan, Bo,et al."Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity".JOURNAL OF NEUROSCIENCE 27.41(2007):11139-11148. |
入库方式： OAI收割
来源：上海神经科学研究所
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