Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats
文献类型：期刊论文
| 作者 | Zhu, Lin ; Yan, Wei ; Qi, Meng ; Hu, Ze Lan ; Lu, Ting Jia ; Chen, Min ; Zhou, Jin ; Hang, Chun Hua ; Shi, Ji Xin |
| 刊名 | ANNALS OF CLINICAL AND LABORATORY SCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 37期号:4页码:356-361 |
| ISSN号 | 0091-7370 |
| 关键词 | brain trauma lung zinc cytokines TNF-alpha IL-8 AIRWAY EPITHELIAL-CELLS HYDROXYETHYL STARCH LABILE ZINC INFLAMMATION PERMEABILITY LUNG EXPRESSION APOPTOSIS RESPONSES RELEASE |
| 通讯作者 | Shi, JX (reprint author), Nanjing Univ, Dept Neurosurg, Sch Med, Jinling Hosp, 305 E Zhongshan Rd, Nanjing 210002, Peoples R China,shijixin52@163.com |
| 英文摘要 | Previous studies have shown that labile zinc and inflammatory mediators participate in many pathophysiological processes. The present study investigated the effects of traumatic brain injury (TBI) on the levels of labile zinc and certain proinflammatory factors in rat lung. Male Wistar rats were randomly assigned to 7 groups as follows: normal group, group with sham operation, and TBI groups that were sacrificed respectively at 1, 6, 24, and 72 hr, and on day 7 post-injury. Pulmonary labile zinc, tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and wet/dry weight ratio were measured at the specified time intervals. TBI caused a gradual increase of pulmonary labile zinc as demonstrated by fluorescence staining with Zinpyr-4 (ZP4). The levels of TNF-alpha and IL-8 and the lung wet/dry weight ratios were higher in the TBI groups compared to the normal and sham-operated groups (p < 0.05). There were highly positive correlations between the intensity of ZP4 fluorescence and the pulmonary levels of TNF-alpha and IL-8. The results suggest that TBI induces rapid increases of labile zinc and inflammatory mediators in lung, which may participate in the pathogenesis of acute lung injury. |
| 学科主题 | Medical Laboratory Technology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1753]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhu, Lin,Yan, Wei,Qi, Meng,et al. Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats[J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE,2007,37(4):356-361. |
| APA | Zhu, Lin.,Yan, Wei.,Qi, Meng.,Hu, Ze Lan.,Lu, Ting Jia.,...&Shi, Ji Xin.(2007).Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats.ANNALS OF CLINICAL AND LABORATORY SCIENCE,37(4),356-361. |
| MLA | Zhu, Lin,et al."Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats".ANNALS OF CLINICAL AND LABORATORY SCIENCE 37.4(2007):356-361. |
入库方式： OAI收割
来源：上海神经科学研究所
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