Selective control of cortical axonal spikes by a slowly inactivating K(+) current
文献类型：期刊论文
| 作者 | Shu, Yousheng
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2007 |
| 卷号 | 104期号:27页码:11453-11458 |
| 关键词 | axon cortex plasticity synaptic transmission NEOCORTICAL PYRAMIDAL NEURONS ACTION-POTENTIAL INITIATION GATED POTASSIUM CHANNELS HIPPOCAMPAL-NEURONS ALPHA-SUBUNIT ION CHANNELS TRANSMITTER RELEASE CEREBELLAR BASKET XENOPUS OOCYTES BETA-SUBUNIT |
| ISSN号 | 0027-8424 |
| 通讯作者 | McCormick, DA (reprint author), Yale Univ, Sch Med, Kavli Inst Neurosci, Dept Neurobiol, 333 Cedar St, New Haven, CT 06510 USA,david.mccormick@yale.edu |
| 英文摘要 | Neurons are flexible electrophysiological entities in which the distribution and properties of ionic channels control their behaviors. Through simultaneous somatic and axonal whole-cell recording of layer 5 pyramidal cells, we demonstrate a remarkable differential expression of slowly inactivating K(+) currents. Depolarizing the axon, but not the soma, rapidly activated a low-threshold, slowly inactivating, outward current that was potently blocked by low doses of 4-aminopyridine, a-dendrotoxin, and rTityustoxin-K alpha. Block of this slowly inactivating current caused a large increase in spike duration in the axon but only a small increase in the soma and could result in distal axons generating repetitive discharge in response to local current injection. Importantly, this current was also responsible for slow changes in the axonal spike duration that are observed after somatic membrane potential change. These data indicate that low-threshold, slowly inactivating K+ currents, containing Kv1.2 alpha subunits, play a key role in the flexible properties of intracortical axons and may contribute significantly to intracortical processing. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1759]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组 |
| 推荐引用方式 GB/T 7714 | Shu, Yousheng. Selective control of cortical axonal spikes by a slowly inactivating K(+) current[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(27):11453-11458. |
| APA | Shu, Yousheng.(2007).Selective control of cortical axonal spikes by a slowly inactivating K(+) current.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(27),11453-11458. |
| MLA | Shu, Yousheng."Selective control of cortical axonal spikes by a slowly inactivating K(+) current".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.27(2007):11453-11458. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。