Study of tauopathies by comparing Drosophila and human tau in Drosophila
文献类型：期刊论文
| 作者 | Chen, Xinping ; Li, Yan ; Huang, Junbo ; Cao, Dawei ; Yang, Guoying ; Liu, Weijie ; Lu, Huimin ; Guo, Aike |
| 刊名 | CELL AND TISSUE RESEARCH
 |
| 出版日期 | 2007 |
| 卷号 | 329期号:1页码:169-178 |
| 关键词 | tau tauopathy comparison conservation Drosophila PAIRED HELICAL FILAMENTS PROTEIN-TAU TRANSGENIC MICE FRONTOTEMPORAL DEMENTIA ALZHEIMERS-DISEASE NERVOUS-SYSTEM NEURODEGENERATION PHOSPHORYLATION GENE AXONOPATHY |
| ISSN号 | 0302-766X |
| 通讯作者 | Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China,akguo@ion.ac.cn |
| 英文摘要 | The microtubule-binding protein tau has been investigated for its contribution to various neurodegenerative disorders. However, the findings from transgenic studies, using the same tau transgene, vary widely among different laboratories. Here, we have investigated the potential mechanisms underlying tauopathies by comparing Drosophila (d-tau) and human (h-tau) tau in a Drosophila model. Overexpression of a single copy of either tau isoform in the retina results in a similar rough eye phenotype. However, co-expression of Par-1 with d-tau leads to lethality, whereas co-expression of Par-1 with h-tau has little effect on the rough eye phenotype. We have found analogous results by comparing larval proteomes. Through genetic screening and proteomic analysis, we have identified some important potential modifiers and tau-associated proteins. These results suggest that the two tau genes differ significantly. This comparison between species-specific isoforms may help to clarify whether the homologous tau genes are conserved. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1760]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, Xinping,Li, Yan,Huang, Junbo,et al. Study of tauopathies by comparing Drosophila and human tau in Drosophila[J]. CELL AND TISSUE RESEARCH,2007,329(1):169-178. |
| APA | Chen, Xinping.,Li, Yan.,Huang, Junbo.,Cao, Dawei.,Yang, Guoying.,...&Guo, Aike.(2007).Study of tauopathies by comparing Drosophila and human tau in Drosophila.CELL AND TISSUE RESEARCH,329(1),169-178. |
| MLA | Chen, Xinping,et al."Study of tauopathies by comparing Drosophila and human tau in Drosophila".CELL AND TISSUE RESEARCH 329.1(2007):169-178. |
入库方式： OAI收割
来源：上海神经科学研究所
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