Dishevelled promotes axon differentiation by regulating atypical protein kinase C
文献类型：期刊论文
| 作者 | Luo, Zhen-Ge
|
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 9期号:7页码:743-U27 |
| 关键词 | HIPPOCAMPAL NEURONAL POLARITY WNT SIGNALING PATHWAY CELL-POLARITY ESTABLISHMENT GSK-3-BETA PAR-1 GUIDANCE ELEGANS COMPLEX CDC42 |
| ISSN号 | 1465-7392 |
| 通讯作者 | Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn |
| 英文摘要 | The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal neurons aPKC is directly regulated by Dishevelled (Dvl), an immediate downstream effector of Wnt. We found that downregulation of Dvl abrogated axon differentiation, whereas Dvl overexpression resulted in multiple axon formation. Interestingly, Dvl was associated with aPKC and this interaction resulted in aPKC stabilization and activation. Furthermore, the multiple axon formation resulting from Dvl overexpression was attenuated by expressing a dominant-negative aPKC in these neurons and overexpression of aPKC prevented the loss of axon caused by Dvl downregulation. Finally, Wnt5a, a noncanonical Wnt, activated aPKC and promoted axon differentiation. The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1762]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_突触信号研究组 |
| 推荐引用方式 GB/T 7714 | Luo, Zhen-Ge. Dishevelled promotes axon differentiation by regulating atypical protein kinase C[J]. NATURE CELL BIOLOGY,2007,9(7):743-U27. |
| APA | Luo, Zhen-Ge.(2007).Dishevelled promotes axon differentiation by regulating atypical protein kinase C.NATURE CELL BIOLOGY,9(7),743-U27. |
| MLA | Luo, Zhen-Ge."Dishevelled promotes axon differentiation by regulating atypical protein kinase C".NATURE CELL BIOLOGY 9.7(2007):743-U27. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。