Role of the integrin-linked kinase (ILK) in detennining neuronal polarity
文献类型：期刊论文
| 作者 | Guo, Wei ; Jiang, Hui ; Gray, Virginia ; Dedhar, Shoukat ; Rao, Yi |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 306期号:2页码:457-468 |
| 关键词 | integrin-linked kinase neuronal polarity glycogen synthase kinase-3 beta Akt PI3K axon determination GLYCOGEN-SYNTHASE KINASE DISPERSED CELL-CULTURE ONLY PROTEIN PINCH HIPPOCAMPAL-NEURONS REGULATES PHOSPHORYLATION THERAPEUTIC TARGET SIGNALING PATHWAYS B/AKT ACTIVATION BINDING-PROTEIN AXON FORMATION |
| ISSN号 | 0012-1606 |
| 通讯作者 | Rao, Y (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Neurol, 303 E Chicago Ave,Ward 10-185, Chicago, IL 60611 USA,y-rao@northwestern.edu |
| 英文摘要 | The establishment of axon-dendrite polarity in mammalian neurons has recently been shown to involve the kinases Akt and GSK-3 beta. Here we report the function of the integrin-linked kinase (ILK) in neuronal polarization. ILK distribution is differential: with more of it present in the axonal tips than that in the dendritic tips of a polarized neuron. Inactivation of ILK by chemical inhibitors, a kinase-inactive mutant or siRNAs inhibited axon formation, whereas a kinase hyperactive ILK mutant induced the formation of multiple axons. Biochemical studies indicate that ILK is upstream of Akt and GSK-3 beta. Manipulations of multiple intracellular components indicate that ILK is functionally upstream of Akt and GSK-3 beta but downstream of PI3K in neuronal polarity. These results reveal a key role of ILK in the formation of neuronal polarity and suggest a signaling pathway important for neuronal polarity. (C) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Developmental Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1767]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Guo, Wei,Jiang, Hui,Gray, Virginia,et al. Role of the integrin-linked kinase (ILK) in detennining neuronal polarity[J]. DEVELOPMENTAL BIOLOGY,2007,306(2):457-468. |
| APA | Guo, Wei,Jiang, Hui,Gray, Virginia,Dedhar, Shoukat,&Rao, Yi.(2007).Role of the integrin-linked kinase (ILK) in detennining neuronal polarity.DEVELOPMENTAL BIOLOGY,306(2),457-468. |
| MLA | Guo, Wei,et al."Role of the integrin-linked kinase (ILK) in detennining neuronal polarity".DEVELOPMENTAL BIOLOGY 306.2(2007):457-468. |
入库方式： OAI收割
来源：上海神经科学研究所
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