Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway
文献类型：期刊论文
| 作者 | Ding, Shan ; Luo, Jian-hong ; Yuan, Xiao-bing |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007 |
| 卷号 | 356期号:4页码:857-863 |
| ISSN号 | 0006-291X |
| 关键词 | semaphorin growth cone guidance turning assays neuropilin cGMP cAMP granule cell development cerebellum AXON GUIDANCE SYNAPTIC PLASTICITY HIPPOCAMPAL AXONS RHO-GTPASES PROTEIN 3A REPULSION COLLAPSE CHANNELS BRAIN |
| 通讯作者 | Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn |
| 英文摘要 | Growth cone extension is guided by extracellular factors during the brain development but the underlying cellular mechanisms remain largely unclear. Here, we examined the potential function of class-3 semaphorins in cultured cerebellar granule cells. We found neuropilin-2 (NP2), the high-affinity receptor for semaphorin-3F (Sema3F), is highly expressed in cerebellar granule cells. An extracellular gradient of Sema3F-triggered an NP2-dependent attractive turning of the growth cone of cultured cerebellar granule cells. This Sema3F-triggered growth cone attraction was abolished by inhibition of the cGMP signaling pathway and reduced by elevating the intracellular cGMP level. Furthermore, Sema3F partially rescued the collapse induced by inhibition of basal cGMP in granule cells. Thus, Sema3F may act as a chemoattractant for the growth cone of cerebellar granule cells through cGMP signaling pathway. (c) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1771]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ding, Shan,Luo, Jian-hong,Yuan, Xiao-bing. Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,356(4):857-863. |
| APA | Ding, Shan,Luo, Jian-hong,&Yuan, Xiao-bing.(2007).Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,356(4),857-863. |
| MLA | Ding, Shan,et al."Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356.4(2007):857-863. |
入库方式： OAI收割
来源：上海神经科学研究所
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