Identification of acid-sensing ion channels in adenoid cystic carcinomas
文献类型：期刊论文
| 作者 | Ye, Jin-Hai ; Gao, Jun ; Wu, Yu-Nong ; Hu, Yong-Jie ; Zhang, Chen-Ping ; Xu, Tian-Le(徐天乐) |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007 |
| 卷号 | 355期号:4页码:986-992 |
| 关键词 | acid-sensing ion channels adenoid cystic carcinomas patch clamp RT-PCR western blotting MUTATIONS CAUSING NEURODEGENERATION MAMMALIAN DEGENERIN MDEG GATED NA+ CHANNEL CELL-LINE CAENORHABDITIS-ELEGANS POTASSIUM CHANNEL H+ CALCIUM PH LYMPHOCYTES |
| ISSN号 | 0006-291X |
| 通讯作者 | Zhang, CP (reprint author), Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol,Shanghai Res Inst Stomatol, Affiliated Peoples Hosp 9, Shanghai 200011, Peoples R China,yjh98001@sjtu.edu.cn |
| 英文摘要 | Tissue acidosis is an important feature of tumor. The response of adenoid cystic carcinoma (ACC) cells to acidic solution was studied using whole-cell patch-clamp recording in the current study. An inward, amiloride-sensitive Na+ current was identified in cultured ACC2 cells while not in normal human salivary gland epithelial cells. Electrophysiological and pharmacological properties of the currents suggest that heteromeric acid-sensing ion channels (ASICs) containing 2a and 3 may be responsible for the proton-induced currents in the majority of ACC-2 cells. Consistent with it, analyses of RT-PCR and Western blotting demonstrated the presences of ASIC2a and 3 in ACC-2 cells. Furthermore, we observed the enhanced expression of ASIC2a and 3 in the sample of ACC tissues. These results indicate that the functional expression of ASICs is characteristic feature of ACC cells. (c) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1776]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ye, Jin-Hai,Gao, Jun,Wu, Yu-Nong,et al. Identification of acid-sensing ion channels in adenoid cystic carcinomas[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,355(4):986-992. |
| APA | Ye, Jin-Hai,Gao, Jun,Wu, Yu-Nong,Hu, Yong-Jie,Zhang, Chen-Ping,&Xu, Tian-Le.(2007).Identification of acid-sensing ion channels in adenoid cystic carcinomas.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,355(4),986-992. |
| MLA | Ye, Jin-Hai,et al."Identification of acid-sensing ion channels in adenoid cystic carcinomas".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 355.4(2007):986-992. |
入库方式： OAI收割
来源：上海神经科学研究所
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