Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation
文献类型：期刊论文
| 作者 | Zhang, Xiaochang ; Xu, Rener ; Zhu, Binggen ; Yang, Xiujuan ; Ding, Xu ; Duan, Shumin ; Xu, Tian ; Zhuang, Yuan ; Han, Min |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2007 |
| 卷号 | 134期号:5页码:901-908 |
| 关键词 | synaptic nuclei neuromuscular junction neonatal lethality nuclear envelope KASH SUN domain nesprin ANC-1 MSP-300 mouse NEMATODE CAENORHABDITIS-ELEGANS NUCLEAR-MEMBRANE PROTEIN NEUROMUSCULAR-JUNCTION ACTIN CYTOSKELETON MUSCLE-FIBERS IN-VIVO DROSOPHILA ENVELOPE KLARSICHT GENE |
| ISSN号 | 0950-1991 |
| 通讯作者 | Xu, RN (reprint author), Fudan Univ, Sch Life Sci, Inst Dev Biol & Mol Med, Shanghai 200433, Peoples R China,rener_xu@fudan.edu.cn |
| 英文摘要 | Proper nuclear positioning is important to cell function in many biological processes during animal development. In certain cells, the KASH-domain-containing proteins have been shown to be associated with the nuclear envelope, and to be involved in both nuclear anchorage and migration. We investigated the mechanism and function of nuclear anchorage in skeletal muscle cells by generating mice with single and double-disruption of the KASH-domain-containing genes Syne1 (also known as Syne-1) and Syne2 (also known as Syne-2). We showed that the deletion of the KASH domain of Syne-1 abolished the formation of clusters of synaptic nuclei and disrupted the organization of non-synaptic nuclei in skeletal muscle. Further analysis indicated that the loss of synaptic nuclei in Syne-1 KASH-knockout mice significantly affected the innervation sites and caused longer motor nerve branches. Although disruption of neither Syne-1 nor Syne-2 affected viability or fertility, Syne-1; Syne-2 double-knockout mice died of respiratory failure within 20 minutes of birth. These results suggest that the KASH-domain-containing proteins Syne-1 and Syne-2 play crucial roles in anchoring both synaptic and non-synaptic myonuclei that are important for proper motor neuron innervation and respiration. |
| 学科主题 | Developmental Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1784]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaochang,Xu, Rener,Zhu, Binggen,et al. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation[J]. DEVELOPMENT,2007,134(5):901-908. |
| APA | Zhang, Xiaochang.,Xu, Rener.,Zhu, Binggen.,Yang, Xiujuan.,Ding, Xu.,...&Han, Min.(2007).Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.DEVELOPMENT,134(5),901-908. |
| MLA | Zhang, Xiaochang,et al."Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation".DEVELOPMENT 134.5(2007):901-908. |
入库方式： OAI收割
来源：上海神经科学研究所
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