Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons
文献类型：期刊论文
| 作者 | Zhang, Yongjun ; Gu, Xuefan ; Yuan, Xiaobing |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 25期号:5页码:1341-1348 |
| 关键词 | apoptosis phenylalanine phenylketonuria RhoA Rho-associated kinase LINKED MENTAL-RETARDATION RHO-ASSOCIATED KINASE SPINAL-CORD-INJURY HIPPOCAMPAL-NEURONS SIGNALING PATHWAYS MYOSIN PHOSPHATASE ENDOTHELIAL-CELLS ENERGY-METABOLISM PROTEIN-KINASE EMBRYONIC RAT |
| ISSN号 | 0953-816X |
| 通讯作者 | Zhang, YJ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Pediat Res, XinHua Hosp, Shanghai 200092, Peoples R China,shanghaiyjzhang@yahoo.com.cn |
| 英文摘要 | Phenylketonuria (PKU) is caused by deficiency of phenylalanine hydroxylase, resulting in an accumulation of phenylalanine in brain tissue and cerebrospinal fluid of phenylketonuria patients. Phenylketonuria is neuropathologically characterized by neuronal cell loss, white matter abnormalities, dendritic simplification, and synaptic density reduction. The neuropathological effect may be due to the 'toxicity' of the high concentration of phenylalanine, while the underlying mechanism remains unclear. In this study, we found that cultured cerebral cortical neurons underwent mitochondria-mediated apoptosis when exposed to phenylalanine. We further demonstrated that phenylalanine induced RhoA activation. Phenylalanine also promoted myosin light chain (MLC) phosphorylation, which might be the result of the activation of Rho-associated kinase (ROCK). The RhoA antagonist, C3 transferase (C3), Rho-associated kinase specific inhibitor, Y-27632, and the overexpression of either dominant negative RhoA or dominant negative Rho-associated kinase inhibited phenylalanine-induced caspase-3 activation and rescued neurons from apoptosis, indicating that the RhoA/Rho-associated kinase signalling pathway plays an important role in phenylalanine-induced neuronal apoptosis. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1785]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, Yongjun,Gu, Xuefan,Yuan, Xiaobing. Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2007,25(5):1341-1348. |
| APA | Zhang, Yongjun,Gu, Xuefan,&Yuan, Xiaobing.(2007).Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons.EUROPEAN JOURNAL OF NEUROSCIENCE,25(5),1341-1348. |
| MLA | Zhang, Yongjun,et al."Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons".EUROPEAN JOURNAL OF NEUROSCIENCE 25.5(2007):1341-1348. |
入库方式： OAI收割
来源：上海神经科学研究所
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