Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation
文献类型：期刊论文
| 作者 | Ge, Woo-Ping ; Duan, Shumin |
| 刊名 | JOURNAL OF NEUROPHYSIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 97期号:3页码:2564-2569 |
| 关键词 | FUNCTIONAL SPECIALIZATION GLUTAMATE TRANSPORTERS HIPPOCAMPAL ASTROCYTES CEREBELLAR CULTURE D-SERINE CURRENTS EXPRESSION CELLS SYNAPSES RELEASE |
| ISSN号 | 0022-3077 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn |
| 英文摘要 | Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation. J Neurophysiol 97: 2564-2569, 2007. First published October 11, 2006; doi:10.1152/jn. 00146.2006. Neuron-glia signaling is important for neural development and functions. This signaling may be regulated by neuronal activity and undergo modification similar to long-term potentiation (LTP) of neuronal synapses, a hallmark of neuronal plasticity. We found that tetanic stimulation of Schaffer collaterals (Sc) in the hippocampus that induced LTP in neurons also resulted in LTP-like persistent elevation of Sc-evoked slow depolarization in perisynaptic astrocytes. The elevated slow depolarization in astrocytes was abolished by NMDA receptor antagonist and K+ channel inhibitors, but not by Ca2+ chelator BAPTA loaded in the recorded astrocytes, suggesting involvement of an increased extracellular K+ accumulation accompanying LTP of neuronal synapses. The increased K+ accumulation and astrocyte depolarization after LTP induction may reduce the efficiency of glial glutamate transporters, which may contribute to the enhanced synaptic efficacy. The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance. |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1786]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ge, Woo-Ping,Duan, Shumin. Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation[J]. JOURNAL OF NEUROPHYSIOLOGY,2007,97(3):2564-2569. |
| APA | Ge, Woo-Ping,&Duan, Shumin.(2007).Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation.JOURNAL OF NEUROPHYSIOLOGY,97(3),2564-2569. |
| MLA | Ge, Woo-Ping,et al."Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation".JOURNAL OF NEUROPHYSIOLOGY 97.3(2007):2564-2569. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。