Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices
文献类型：期刊论文
| 作者 | Huang, H. -P. ; Wang, S. -R. ; Yao, W. ; Zhang, C. ; Zhou, Y. ; Chen, X. -W. ; Zhang, B. ; Xiong, W. ; Wang, L. -Y. ; Zheng, L. -H. ; Landry, M. ; Hokfelt, T. ; Xu, Z. -Q. D. ; Zhou, Z. |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2007 |
| 卷号 | 104期号:4页码:1401-1406 |
| 关键词 | amperometry patch-clamp somatic release brain slice catecholamine ADRENAL CHROMAFFIN CELLS ENDOGENOUS NORADRENALINE RELEASE DUAL-PROBE MICRODIALYSIS GANGLION NEURONS STRUCTURAL ORGANIZATION NOREPINEPHRINE RELEASE AMPEROMETRIC DETECTION NORADRENERGIC NEURONS SEROTONERGIC NEURONS MEMBRANE-PROPERTIES |
| ISSN号 | 0027-8424 |
| 通讯作者 | Hokfelt, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tomas.hokfelt@neuro.ki.se ; zzhou@pku.edu.cn |
| 英文摘要 | The locus coeruleus (LC) harbors a compact group of noradrenergic cell bodies projecting to virtually all parts of the central nervous system. By using combined measurements of amperometry and patch-clamp, quantal vesicle release of noradrenaline (NA) was detected as amperometric spikes, after depolarization of the LC neurons. After a pulse depolarization, the average latency of amperometric spikes was 1,870 ms, whereas the latency of glutamate-mediated excitatory postsynaptic currents was 1.6 ms. A substantial fraction of the depolarization-induced amperometric spikes originated from the somata. In contrast to glutamate-mediated excitatory postsynaptic currents, NA secretion was strongly modulated by the action potential frequency (0.5-50 Hz). Somatodendritic NA release from LC upon enhanced cell activity produced autoinhibition of firing and of NA release. We conclude that, in contrast to classic synaptic transmission, quantal NA release from LC somata is characterized by a number of distinct properties, including long latency and high sensitivity to action potential frequency. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1789]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Huang, H. -P.,Wang, S. -R.,Yao, W.,et al. Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(4):1401-1406. |
| APA | Huang, H. -P..,Wang, S. -R..,Yao, W..,Zhang, C..,Zhou, Y..,...&Zhou, Z..(2007).Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(4),1401-1406. |
| MLA | Huang, H. -P.,et al."Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.4(2007):1401-1406. |
入库方式： OAI收割
来源：上海神经科学研究所
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