The development and modulation of nociceptive circuitry
文献类型：期刊论文
| 作者 | Xu Zhang ; Lan Bao |
| 刊名 | CURRENT OPINION IN NEUROBIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:4页码:460-466 |
| 关键词 | DORSAL-ROOT GANGLION DELTA-OPIOID-RECEPTOR PRIMARY AFFERENT NEURONS PRIMARY SENSORY NEURONS NEUROPATHIC PAIN NEUROTROPHIC FACTOR SPINAL-CORD NERVE INJURY POSTSYNAPTIC LOCALIZATION GENE-EXPRESSION |
| ISSN号 | 0959-4388 |
| 通讯作者 | Xu, Z (reprint author), Shanghai Inst Biol Sci, Key Lab Neurobiol, Inst Neurosci, Shanghai, Peoples R China,xu.zhang@ion.ac.cn |
| 英文摘要 | Nociceptive circuitry processes the signals evoked by activating specialized peripheral sensory receptors for pain perception. Recent studies show that the neuronal phenotypes in the dorsal root ganglia and spinal dorsal horn are determined by distinct sets of transcription factors during development. Anatomical analyses with genetic approaches demonstrate that each subset of nociceptive sensory neurons has topographically distinct circuits at both spinal and brain levels.. Moreover, the sensitivity of primary afferents can be. rapidly regulated not only by phosphorylation of receptors, ion channels and associated regulatory proteins but also by stimulus-induced cell surface expression of G-protein-coupled receptors. In chronic pain states the molecular characteristics of spinal nociceptive circuits are altered, enabling normal peripheral stimuli to induce pain hypersensitivity. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1808]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu Zhang,Lan Bao. The development and modulation of nociceptive circuitry[J]. CURRENT OPINION IN NEUROBIOLOGY,2006,16(4):460-466. |
| APA | Xu Zhang,&Lan Bao.(2006).The development and modulation of nociceptive circuitry.CURRENT OPINION IN NEUROBIOLOGY,16(4),460-466. |
| MLA | Xu Zhang,et al."The development and modulation of nociceptive circuitry".CURRENT OPINION IN NEUROBIOLOGY 16.4(2006):460-466. |
入库方式： OAI收割
来源：上海神经科学研究所
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