Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats
文献类型：期刊论文
| 作者 | Zhang, LH ; Xu, L ; Xu, TL(徐天乐) |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 344期号:3页码:721-726 |
| 关键词 | glycine receptor GABA(A) receptor hippocampus brain slice synaptic transmission short-term plasticity paired-pulse depression paired-pulse facilitation SYNAPTIC PLASTICITY DENTATE GYRUS CROSS-INHIBITION NEURONS SYNAPSES DEPRESSION MEMORY BRAIN GAIN |
| ISSN号 | 0006-291X |
| 通讯作者 | Xu, TL (reprint author), Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their roles in synaptic transmission are unclear. In this study, we examined the effect of GlyR activation on paired-pulse stimulation of the whole-cell postsynaptic currents (PSCs) in the Schaffer-CA1 synapses in rat hippocampal slices. Bath application of glycine reduced the amplitude of PSCs, accompanied by all increase ill holding current and resting conductance. Moreover, glycine application increased the paired-pulse ratio (PPR) of PSCs significantly, all effect largely abolished by the GlyR specific antagonist strychnine. Interestingly, glycine application had no significant effect oil either the amplitude or the PPR of excitatory postsynaptic currents (EPSCs). Our findings suggest that GlyR activation regulates hippocampal short-term plasticity by altering GABAergic neurotransmission. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1817]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, LH,Xu, L,Xu, TL. Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,344(3):721-726. |
| APA | Zhang, LH,Xu, L,&Xu, TL.(2006).Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,344(3),721-726. |
| MLA | Zhang, LH,et al."Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 344.3(2006):721-726. |
入库方式： OAI收割
来源：上海神经科学研究所
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