Activity-induced rapid synaptic maturation mediated by presynaptic Cdc42 signaling
文献类型：期刊论文
| 作者 | Shen, WH ; Wu, B ; Zhang, ZJ ; Dou, Y ; Rao, ZR ; Chen, YR ; Duan, SM |
| 刊名 | NEURON
 |
| 出版日期 | 2006 |
| 卷号 | 50期号:3页码:401-414 |
| 关键词 | LONG-TERM-POTENTIATION CULTURED HIPPOCAMPAL-NEURONS BRAIN MYOSIN-V NEUROTROPHIC FACTOR ACTIN CYTOSKELETON SILENT SYNAPSES NEUROTRANSMITTER RELEASE INHIBITORY SYNAPSES RHO GTPASES PLASTICITY |
| ISSN号 | 0896-6273 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn |
| 英文摘要 | Maturation of presynaptic transmitter secretion machinery is a critical step in synaptogenesis. Here we report that a brief train of presynaptic action potentials rapidly converts early nonfunctional contacts between cultured hippocampal neurons into functional synapses by enhancing presynaptic glutamate release. The enhanced release was confirmed by a marked increase in the number of depolarization-induced FM4-64 puncta in the presynaptic axon. This rapid presynaptic maturation can be abolished by treatments that interfered with presynaptic BDNF and Cdc42 signaling or actin polymerization. Activation of Cdc42 by applying BDNF or bradykinin mimicked the effect of electrical activity in promoting synaptic maturation. Furthermore, activity-induced increase in presynaptic actin polymerization, as revealed by increased concentration of actin-YFP at axon boutons, was abolished by inhibiting BDNF and Cdc42 signaling. Thus, rapid presynaptic maturation induced by neuronal activity is mediated by presynaptic activation of the Cdc42 signaling pathway. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1824]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Shen, WH,Wu, B,Zhang, ZJ,et al. Activity-induced rapid synaptic maturation mediated by presynaptic Cdc42 signaling[J]. NEURON,2006,50(3):401-414. |
| APA | Shen, WH.,Wu, B.,Zhang, ZJ.,Dou, Y.,Rao, ZR.,...&Duan, SM.(2006).Activity-induced rapid synaptic maturation mediated by presynaptic Cdc42 signaling.NEURON,50(3),401-414. |
| MLA | Shen, WH,et al."Activity-induced rapid synaptic maturation mediated by presynaptic Cdc42 signaling".NEURON 50.3(2006):401-414. |
入库方式： OAI收割
来源：上海神经科学研究所
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