Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats
文献类型：期刊论文
| 作者 | Zheng, CH ; Feng, LY |
| 刊名 | JOURNAL OF CELLULAR PHYSIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 207期号:2页码:530-539 |
| 关键词 | GRANULE CELL-MIGRATION RHESUS-MONKEY NEURONAL MIGRATION CEREBRAL-CORTEX EXPRESSION RECEPTORS REELIN GOLGI DIFFERENTIATION TRANSFORMATION |
| ISSN号 | 0021-9541 |
| 通讯作者 | Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, 555 Zu Chongzhi Rd, Shanghai 201203, Peoples R China,lyfeng@sibs.ac.cn |
| 英文摘要 | In the rodent hippocampus, the radial glial scaffold consists of radial glial cells (RGCs) and plays important roles in neurogenesis in this area after birth. However, the mechanisms that maintain the radial glial scaffold in the postnatal dentate gyrus (DG) area remain elusive. In the present work, we studied the role of Neuregulin (NRG) in the formation and maintenance of the radial glial scaffold in the hippocampal DG of postnatal rats using slice culture. We found that ErbB4 receptors were expressed in vimentin-positive RGCs in DG of postnatal day 6 (P6) rats. Treatment with NRG and Ab-3, the inhibitor of ErbB4, revealed that in P6 rats exogenous NRG promoted the proliferation of Vimentin-positive RGCs in DG. On the other hand, endogenous NRG was found necessary for maintaining the characteristic morphological and immunohistochemical features of these cells. These results indicated that NRG plays a critical role in the formation and maintenance of the radial glial scaffold in the hippocampal DG of postnatal rats. |
| 学科主题 | Cell Biology ; Physiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1829]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zheng, CH,Feng, LY. Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2006,207(2):530-539. |
| APA | Zheng, CH,&Feng, LY.(2006).Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats.JOURNAL OF CELLULAR PHYSIOLOGY,207(2),530-539. |
| MLA | Zheng, CH,et al."Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats".JOURNAL OF CELLULAR PHYSIOLOGY 207.2(2006):530-539. |
入库方式： OAI收割
来源：上海神经科学研究所
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