Thiopental inhibits glycine receptor function in acutely dissociated rat spinal dorsal horn neurons
文献类型：期刊论文
| 作者 | Yang, CX ; Xu, TL(徐天乐) |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2006 |
| 卷号 | 397期号:3页码:196-200 |
| 关键词 | acutely dissociated neuron thiopental glycine receptors spinal cord dorsal horn whole-cell patch-clamp recording GENERAL-ANESTHETICS COMMISSURAL NEURONS CROSS-INHIBITION GABA(A) MODULATION MECHANISMS PROPOFOL |
| ISSN号 | 0304-3940 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Whole-cell patch-clamp was used to assess the modulatory effect of thiopental (Thio) on glycine (Gly) receptor in mechanically dissociated rat spinal dorsal horn neurons. It was found that Thio inhibited the amplitude, accelerated the desensitization and prolonged the deactivation of Gly-induced currents (I-Gly) in a concentration-dependent manner. In addition, a rebound current occurred after washout of the co-application of Gly and Thio in most neurons tested. Moreover, the inhibitory effect of Thio was not the result of cross-inhibition between Gly and GABA(A) receptors. Furthermore, taurine-induced currents, a low-affinity agonist for Gly receptors, were also markedly inhibited by Thio in a similar way to I-Gly. These results indicate that Thio suppresses Gly receptor function and suggest that Thio anesthetic actions might not be mediated by Gly receptors. We speculate that the weak muscle relaxation and the limited analgesic effects observed during Thio anesthesia may attribute to its inhibitory effects on Gly receptors. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1831]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yang, CX,Xu, TL. Thiopental inhibits glycine receptor function in acutely dissociated rat spinal dorsal horn neurons[J]. NEUROSCIENCE LETTERS,2006,397(3):196-200. |
| APA | Yang, CX,&Xu, TL.(2006).Thiopental inhibits glycine receptor function in acutely dissociated rat spinal dorsal horn neurons.NEUROSCIENCE LETTERS,397(3),196-200. |
| MLA | Yang, CX,et al."Thiopental inhibits glycine receptor function in acutely dissociated rat spinal dorsal horn neurons".NEUROSCIENCE LETTERS 397.3(2006):196-200. |
入库方式： OAI收割
来源：上海神经科学研究所
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