Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead
文献类型：期刊论文
| 作者 | Wang, W ; Duan, B ; Xu, H ; Xu, L ; Xu, TL(徐天乐) |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2006 |
| 卷号 | 281期号:5页码:2497-2505 |
| 关键词 | LONG-TERM POTENTIATION PROTEIN-KINASE-C RAT HIPPOCAMPAL-NEURONS SYNAPTIC PLASTICITY SENSORY NEURONS NA+ CHANNEL CA2+ CONTRIBUTES INCREASES EXPOSURE |
| ISSN号 | 0021-9258 |
| 通讯作者 | Xu, L (reprint author), Chinese Acad Sci, Lab Learning & Memory, Kunming Inst Zool, 32 Jiaochang Donglu, Kunming 650223, Yunnan, Peoples R China,lxu@vip.163.com |
| 英文摘要 | Acid-sensing ion channels (ASICs) are emerging as fundamental players in the regulation of neural plasticity and in pathological conditions. Here we showed that lead (Pb2+), a well known neurotoxic metal ion, reversibly and concentration-dependently inhibited ASIC currents in the acutely dissociated spinal dorsal horn and hippocampal CA1 neurons of rats. In vitro expression of ASIC subunits in combination demonstrated that both ASIC1 and -3 subunits were sensitive to Pb2+. Mechanistically, Pb2+ reduced the pH sensitivity of ASICs independent of membrane voltage change. Moreover, Pb2+ inhibited the ASIC-mediated membrane depolarization and the elevation of intracellular Ca2+ concentration. In addition, we compared the effect of Pb2+ with that of Ca2+ or amiloride to explore the possible interactions of Pb2+ and Ca2+ in regulating ASICs, and we found that Pb2+ inhibited ASIC currents independent of the amiloride/Ca2+ blockade. Because ASIC1b and -3 subunits are mainly expressed in peripheral neurons, our data identified ASIC1a-containing Ca2+-permeable ASIC as a novel central target of Pb2+ action, which may contribute to Pb2+ neurotoxicity. |
| 学科主题 | Biochemistry & Molecular Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1838]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, W,Duan, B,Xu, H,et al. Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2006,281(5):2497-2505. |
| APA | Wang, W,Duan, B,Xu, H,Xu, L,&Xu, TL.(2006).Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead.JOURNAL OF BIOLOGICAL CHEMISTRY,281(5),2497-2505. |
| MLA | Wang, W,et al."Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead".JOURNAL OF BIOLOGICAL CHEMISTRY 281.5(2006):2497-2505. |
入库方式： OAI收割
来源：上海神经科学研究所
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