Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss
文献类型：期刊论文
| 作者 | Tao, YM ; Yan, D ; Yang, QY ; Zeng, R ; Wang, YZ |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 26期号:3页码:1038-1050 |
| 关键词 | B TRANSCRIPTION FACTORS CYTOCHROME-C RELEASE BCL-X IN-VITRO LYMPHOCYTE-PROLIFERATION SENSORY NEURONS PROTEIN-KINASE MICE LACKING CELL-DEATH ACTIVATION |
| ISSN号 | 0270-7306 |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, SIBS, Inst Neurosci,Grad Sch, Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | Low intracellular K+ concentration ([K+](i)) promotes apoptosis and blocking K+ loss prevents apoptosis, but the mechanism of action of low [K+](i) remains unclear. Here, we show that low [K+](i) increases NF-kappa B transcriptional activity by enhancing its binding to the promoter of target genes without affecting its activation and nuclear translocation in cortical neurons deprived of serum. Low K+ concentration promotes NF-kappa B/DNA binding through direct effects on the interaction of NF-kappa B dimers with DNA. Up-regulation of proapoptotic protein Bcl-X-S and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or downregulation of NF-kappa B and by prevention of K+ loss. Thus, a direct action of K+ on NF-kappa B/DNA binding regulates gene transcription related to neuronal apoptosis. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1842]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Tao, YM,Yan, D,Yang, QY,et al. Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss[J]. MOLECULAR AND CELLULAR BIOLOGY,2006,26(3):1038-1050. |
| APA | Tao, YM,Yan, D,Yang, QY,Zeng, R,&Wang, YZ.(2006).Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss.MOLECULAR AND CELLULAR BIOLOGY,26(3),1038-1050. |
| MLA | Tao, YM,et al."Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss".MOLECULAR AND CELLULAR BIOLOGY 26.3(2006):1038-1050. |
入库方式： OAI收割
来源：上海神经科学研究所
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