Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo
文献类型：期刊论文
| 作者 | Dong, Zhifang ; Zhong, Weixia ; Tian, Meng ; Han, Huili ; Cao, Jun ; Xu, Tianle(徐天乐） ; Luo, Jianhong ; Xu, Lin |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:12页码:1017-1025 |
| 关键词 | opiate withdrawal long-term potentiation hippocampal CA1 stress LONG-TERM POTENTIATION SYNAPTIC PLASTICITY GLUCOCORTICOID-RECEPTORS MORPHINE-WITHDRAWAL POSSIBLE MECHANISMS RAT HIPPOCAMPUS SPATIAL MEMORY DRUG-ABUSE CA1 REGION DEPRESSION |
| ISSN号 | 1050-9631 |
| 通讯作者 | Luo, JH (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China,luojianhong@zju.edu.cn |
| 英文摘要 | Stress impairs hippocampal long-term potentiation (LTP), but it is unknown whether the stress evoked by opiate withdrawal has the same effect. Here the authors report that opiate withdrawal for 4 days does not influence basal synaptic transmission, but results in a greatly increased LTP in hippocampal CA1 area in anesthetized rats. Elevated-platform stress enabled a large LTP in rats withdrawn for only 18 h, but the glucocorticoid receptor antagonist RU38486 (twice per day for 3 days) prevented the large LTP on 4 days withdrawal. Moreover, 4 days withdrawal enhanced the NMDAR-mediated EPSCs, in which the NR2A-containing NMDAR-mediated EPSC was increased but the NR2B-containing NMDAR-mediated EPSC was decreased. These results suggest that adaptive changes of the NMDAR and glucocorticoid receptor functions during 4 days of opiate withdrawal may enable stress to facilitate hippocampal LTP, potentially contributing to the opiate withdrawal experience-dependent modifications of hippocampal functions. (c) 2006 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1844]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Dong, Zhifang,Zhong, Weixia,Tian, Meng,et al. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo[J]. HIPPOCAMPUS,2006,16(12):1017-1025. |
| APA | Dong, Zhifang.,Zhong, Weixia.,Tian, Meng.,Han, Huili.,Cao, Jun.,...&Xu, Lin.(2006).Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.HIPPOCAMPUS,16(12),1017-1025. |
| MLA | Dong, Zhifang,et al."Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo".HIPPOCAMPUS 16.12(2006):1017-1025. |
入库方式： OAI收割
来源：上海神经科学研究所
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