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Absence of GABA type A signaling in adult medial habenular neurons
文献类型：期刊论文
| 作者 | Wang, D. -G. ; Gong, N. ; Luo, B. ; Xu, T. -L. |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 141期号:1页码:133-141 |
| 关键词 | central inhibition synaptic balance KCC2 GABA signaling circadian rhythm habenular nucleus CENTRAL-NERVOUS-SYSTEM K-CL COTRANSPORTER RECTIFYING CHLORIDE CONDUCTANCE RAT-BRAIN POSTSYNAPTIC INHIBITION DIFFERENTIAL EXPRESSION MOLECULAR-CLONING KCC2 EXPRESSION MESSENGER-RNAS IN-VIVO |
| ISSN号 | 0306-4522 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Neural inhibition in the brain is mainly mediated by ionotropic GABA type A receptors. Apart from the GABA type A receptors, both K+-Cl- cotransporter isoform 2 and the GABA-synthesizing enzyme, glutamic acid decarboxylase, are essential determinants for GABA type A receptor-mediated inhibition. By using immunofluorescent staining, we observed that K+-Cl- cotransporter isoform 2, GABA type A receptor beta 2/3 subunits and a presynaptically localized glutamic acid decarboxylase isoform, glutamic acid decarboxylase 65, were all absent in adult Sprague-Dawley rat medial habenular nucleus, while immunopositive staining for glutamic acid decarboxylase 67, GABA and GABA type B receptor type 2 subunit were present in the medial habenular nucleus. Consistent with the lack of GABA type A signaling as detected by immunohistochemistry, GABA (100 ILM) evoked no measurable currents in the medial habenular nucleus but induced bicuculline-sensitive currents in the lateral habenular nucleus and in the CA1 area of hippocampus. We also failed to record miniature inhibitory postsynaptic currents in medial habenular nucleus neurons. These results support the idea that GABAergic transmission in medial habenular nucleus is probably not mediated by any of the most common GABA type A receptor subtypes. Our data suggest that GABA type B receptor-mediated inhibition may play a role in balancing neuronal excitation in this special region. Further exploration for factors determining medial habenular nucleus neural inhibition will lead to a more complete understanding of control of synaptic balance in the CNS. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1847]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, D. -G.,Gong, N.,Luo, B.,et al. Absence of GABA type A signaling in adult medial habenular neurons[J]. NEUROSCIENCE,2006,141(1):133-141. |
| APA | Wang, D. -G.,Gong, N.,Luo, B.,&Xu, T. -L..(2006).Absence of GABA type A signaling in adult medial habenular neurons.NEUROSCIENCE,141(1),133-141. |
| MLA | Wang, D. -G.,et al."Absence of GABA type A signaling in adult medial habenular neurons".NEUROSCIENCE 141.1(2006):133-141. |
入库方式： OAI收割
来源：上海神经科学研究所
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