Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
文献类型：期刊论文
| 作者 | Wu, LJ ; Toyoda, H ; Zhao, MG ; Lee, YS ; Tang, JR ; Ko, SW ; Jia, YH ; Shum, FWF ; Zerbinatti, CV ; Bu, GJ ; Wei, F ; Xu, TL(徐天乐) ; Muglia, LJ ; Chen, ZF ; Auberson, YP ; Kaang, BK ; Zhuo, M |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 25期号:48页码:11107-11116 |
| 关键词 | NMDA receptors NR2B anterior cingulate cortex inflammation pain hyperalgesia ANTERIOR CINGULATE CORTEX LONG-TERM-POTENTIATION D-ASPARTATE RECEPTORS MOTOR PROTEIN KIF17 GLUTAMATE RECEPTORS TYROSINE PHOSPHORYLATION DORSAL-HORN PHARMACOLOGICAL CHARACTERIZATION SYNAPTIC PLASTICITY GENETIC ENHANCEMENT |
| ISSN号 | 0270-6474 |
| 通讯作者 | Zhuo, M (reprint author), Univ Toronto, Dept Physiol, Fac Med, Ctr Study Pain, Med Sci Bldg,Room 3342,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada,min.zhuo@utoronto.ca |
| 英文摘要 | Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions. Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC). In freely moving mice, the increase in NR2B receptors after inflammation contributed to enhanced NMDA receptor-mediated responses in the ACC. Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation. Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1864]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wu, LJ,Toyoda, H,Zhao, MG,et al. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation[J]. JOURNAL OF NEUROSCIENCE,2005,25(48):11107-11116. |
| APA | Wu, LJ.,Toyoda, H.,Zhao, MG.,Lee, YS.,Tang, JR.,...&Zhuo, M.(2005).Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.JOURNAL OF NEUROSCIENCE,25(48),11107-11116. |
| MLA | Wu, LJ,et al."Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation".JOURNAL OF NEUROSCIENCE 25.48(2005):11107-11116. |
入库方式： OAI收割
来源：上海神经科学研究所
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